2-dehydropantoate 2-reductase (PA4397)

Identification
Name: 2-dehydropantoate 2-reductase
Synonyms:
  • Ketopantoate reductase
  • KPA reductase
  • KPR
Gene Name: panE
Enzyme Class:
Biological Properties
General Function: Involved in oxidation-reduction process
Specific Function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Cellular Location: Cytoplasm (Potential)
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
2-Dehydropantoate + Hydrogen ion + NADPH ↔ NADP + (R)-Pantoate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
(R)-Pantoate + NADP ↔ 2-Dehydropantoate + NADPH + Hydrogen ion
ReactionCard
SMPDB Reactions:
2-dehydropantoate+NADPH+Thumb+Thumb+Thumb → Thumb+(R)-pantoate+Thumb
2-dehydropantoate + NADPH + Hydrogen ion + 2-Dehydropantoate + NADPH → NADP + (R)-pantoate + (R)-Pantoate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
2-Dehydropantoate + Hydrogen ion + NADPH ↔ NADP + (R)-Pantoate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
(R)-Pantoate + NADP ↔ 2-Dehydropantoate + NADPH + Hydrogen ion
ReactionCard
Thumb+Thumb ← Thumb+Thumb+Thumb
(R)-Pantoate + NADP ← Hydrogen ion + 2-Dehydropantoate + NADPH
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
(R)-Pantoate + NADP → 2-Dehydropantoate + NADPH
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000865(R)-PantoateMetaboCard
PAMDB0005762-DehydropantoateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
binding
catalytic activity
coenzyme binding
cofactor binding
NADP or NADPH binding
nucleotide binding
oxidoreductase activity
Process
cellular metabolic process
coenzyme biosynthetic process
coenzyme metabolic process
cofactor metabolic process
metabolic process
oxidation reduction
pantothenate biosynthetic process
Gene Properties
Locus tag: PA4397
Strand: +
Entrez Gene ID: 881354
Accession: NP_253087.1
GI: 15599593
Sequence start: 4927036
Sequence End: 4927947
Sequence Length: 911
Gene Sequence: 
>PA4397
ATGACCTGGCATATCCTCGGCGCCGGTAGCCTCGGCAGCCTCTGGGCCGCGCGCCTCGGGCGCGCCGGCCTGCCCGTCCGCCTGATCCTGCGCGACCGCCAGCGCCTGCGCCGCTACCAACAGGCCGGCGGACTGAGCCTGGTGGAAGACGGCCAGGCCAGCCTCTACCCGATCGCCGCGGAAACCCCGGACGGCGGGCAACCCATCCAGCGCCTGCTGCTGGCCTGCAAGGCCTACGACGCGGAGGAAGCCGCCTCCAGCGTGGCCCATCGCCTGGCCGGCAACGCCGAACTGCTGTTGCTGCAGAACGGCCTGGGCAGCCAGCAGGCGGTCGCCGCCCGCCTGCCGCGCAGCCGCTGCCTGTTCGCCTCCAGCACCGAAGGCGCGTTCCGCGATGGCGATTTCCGCGTGGTCTTCGCCGGCCGGGGGCACACCTGGCTCGGCGATCCGCGCGACACAAACGCCCCCGCCTGGCTGACGCAGCTGTCCCAGGCCGGGATCCCGCACAGTTGGAGCGACGACATCCTCGAACGGCTGTGGCGCAAGCTGGCCCTGAACTGCGCGATCAACCCGCTGACCGTCCTCCACGATTGCCGCAACGGCGGCCTGCGGCAGCACCCGGAAGAGATCGCCGCGCTTTGCGACGAACTCGGCCAGTTGCTCCACGCCAGCGGCTACGACGCCGCCGCCAGGAGCCTGCTGGAGGATGTCCGGGCGGTGATCGACGCCACCGCGGCCAACTATTCCTCGATGCATCAGGACGTCACCCGCGGCCGGCGCACGGAAATCGGCTACCTGCTCGGCTACGCCTGCCAGCACGGGCAGCGCCTGGGACTACCGCTGCCGCGCCTGGGAACCTTGCTCGCCCGCCTCCAGGCCCATCTGCGCCAGCGCGGTTTGCCCGACCGCTAA
Protein Properties
Protein Residues: 303
Protein Molecular Weight: 33.1 kDa
Protein Theoretical pI: 8.82
Hydropathicity (GRAVY score): -0.218
Charge at pH 7 (predicted): 7.22
Protein Sequence: 
>PA4397
MTWHILGAGSLGSLWAARLGRAGLPVRLILRDRQRLRRYQQAGGLSLVEDGQASLYPIAAETPDGGQPIQRLLLACKAYDAEEAASSVAHRLAGNAELLLLQNGLGSQQAVAARLPRSRCLFASSTEGAFRDGDFRVVFAGRGHTWLGDPRDTNAPAWLTQLSQAGIPHSWSDDILERLWRKLALNCAINPLTVLHDCRNGGLRQHPEEIAALCDELGQLLHASGYDAAARSLLEDVRAVIDATAANYSSMHQDVTRGRRTEIGYLLGYACQHGQRLGLPLPRLGTLLARLQAHLRQRGLPDR
References
External Links:
Resource Link
Genome ID: PA4397
Entrez Gene ID: 881354
NCBI Protein ID: 15599593
General Reference: PaperBLAST - Find papers about PA4397 and its homologs