tRNA (guanine-N(1)-)-methyltransferase (PA3743)

Identification
Name: tRNA (guanine-N(1)-)-methyltransferase
Synonyms:
  • M1G-methyltransferase
  • tRNA [GM37] methyltransferase
Gene Name: trmD
Enzyme Class:
Biological Properties
General Function: Involved in RNA binding
Specific Function: Specifically methylates guanosine-37 in various tRNAs
Cellular Location: Cytoplasm (Potential)
KEGG Pathways: Not Available
KEGG Reactions:
Thumb ↔ Thumb
S-Adenosylmethionine ↔ S-Adenosylhomocysteine
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb ↔ Thumb
S-Adenosylmethionine ↔ S-Adenosylhomocysteine
ReactionCard
Thumb
a tRNA + a tRNA + S-adenosyl-L-methionine = tRNA containing N1-methylguanine + S-adenosyl-L-homocysteine
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Guanine37-in-tRNA+PAMDB000289 → tRNA-Containing-N1-Methylguanine-37+PAMDB000205+PAMDB001633
Guanine37-in-tRNA + S-Adenosylmethionine → tRNA-Containing-N1-Methylguanine-37 + S-Adenosylhomocysteine + Hydrogen ion
ReactionCard
Guanine9-in-tRNA+PAMDB000289 → tRNA-Containing-N1-Methylguanine-9+PAMDB000205+PAMDB001633
Guanine9-in-tRNA + S-Adenosylmethionine → tRNA-Containing-N1-Methylguanine-9 + S-Adenosylhomocysteine + Hydrogen ion
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000205S-AdenosylhomocysteineMetaboCard
PAMDB000289S-AdenosylmethionineMetaboCard
GO Classification:
Function
binding
catalytic activity
methyltransferase activity
nucleic acid binding
RNA binding
RNA methyltransferase activity
transferase activity
transferase activity, transferring one-carbon groups
tRNA (guanine) methyltransferase activity
tRNA (guanine-N1-)-methyltransferase activity
tRNA methyltransferase activity
Process
cellular macromolecule metabolic process
macromolecule metabolic process
metabolic process
ncRNA metabolic process
RNA metabolic process
tRNA metabolic process
tRNA processing
Gene Properties
Locus tag: PA3743
Strand: -
Entrez Gene ID: 880357
Accession: NP_252432.1
GI: 15598938
Sequence start: 4195400
Sequence End: 4196158
Sequence Length: 758
Gene Sequence: 
>PA3743
ATGGACAAGCGTTTGTGGGTGGGCGTCGTCAGCATCTTTCCGGAGATGTTCCGCGCGATCAGTGACTATGGCATCACCAGCCGTGCGGTAAAGCAGGGGTTGCTCACGCTGACCTGCTGGAATCCACGGGACTACACCGAGGACCGCCACCAGACGGTGGACGACCGGCCCTTCGGCGGTGGCCCTGGCATGGTGATGAAGATCAAGCCTCTGGAGGGCGCGCTGGCGGATGCCAGGCAAGCCGCCGGGGGCAGGAAGGCGAAGGTGATCTACCTTTCGCCGCAAGGCCGCCAGCTGACGCAGGCGGGCGTACGCGAACTGGCCGAAGAGGAAGCGTTGATCCTCATCGCCGGGCGCTACGAAGGCATCGACGAGCGCTTCATCGAAGAGCACGTCGATGAAGAATGGTCGATCGGCGATTATGTCCTGTCCGGCGGTGAGTTGCCGGCCATGGTGCTGGTCGATGCAGTGACGCGGTTGCTGCCCGGTGCATTGGGTCATGCAGATTCCGCCGAGGAGGACTCCTTCACGGATGGCCTGCTCGACTGCCCGCACTACACCCGACCCGAGGTGTACGCGGACAAACGTGTTCCTGAAGTGTTGCTCAGTGGCAACCATGAACACATCCGGCGTTGGCGTTTGCAGCAGGCCCTTGGGCGGACCTGGGAACGACGCGCCGATCTTCTGGATAGCCGCTCGCTTTCTGGAGAAGAGCAGAAGCTGCTGGCGGAATATATCCGTCAGCGGGACGATAGTTAA
Protein Properties
Protein Residues: 252
Protein Molecular Weight: 28.4 kDa
Protein Theoretical pI: 4.89
Hydropathicity (GRAVY score): -0.461
Charge at pH 7 (predicted): -9.61
Protein Sequence: 
>PA3743
MDKRLWVGVVSIFPEMFRAISDYGITSRAVKQGLLTLTCWNPRDYTEDRHQTVDDRPFGGGPGMVMKIKPLEGALADARQAAGGRKAKVIYLSPQGRQLTQAGVRELAEEEALILIAGRYEGIDERFIEEHVDEEWSIGDYVLSGGELPAMVLVDAVTRLLPGALGHADSAEEDSFTDGLLDCPHYTRPEVYADKRVPEVLLSGNHEHIRRWRLQQALGRTWERRADLLDSRSLSGEEQKLLAEYIRQRDDS
References
External Links:
Resource Link
Genome ID: PA3743
Entrez Gene ID: 880357
NCBI Protein ID: 15598938
General Reference: PaperBLAST - Find papers about PA3743 and its homologs