Thiol:disulfide interchange protein DsbC (PA3737)

Identification
Name: Thiol:disulfide interchange protein DsbC
Synonyms: Not Available
Gene Name: dsbC
Enzyme Class:
Biological Properties
General Function: Involved in cell redox homeostasis
Specific Function: Acts as a disulfide isomerase, interacting with incorrectly folded proteins to correct non-native disulfide bonds. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by DsbD
Cellular Location: Periplasm
KEGG Pathways:
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    protein disulfide isomerase II (oxidized)+2 Thumb → protein disulfide isomerase II (reduced)+Thumb
    protein disulfide isomerase II (oxidized) + 2 Glutathione → protein disulfide isomerase II (reduced) + Glutathione disulfide
    ReactionCard
    Complex Reactions:
    fused thiol:disulfide interchange protein (reduced)+protein disulfide isomerase II (oxidized) → fused thiol:disulfide interchange protein (oxidized)+protein disulfide isomerase II (reduced)
    fused thiol:disulfide interchange protein (reduced) + protein disulfide isomerase II (oxidized) → fused thiol:disulfide interchange protein (oxidized) + protein disulfide isomerase II (reduced)
    ReactionCard
    protein disulfide isomerase II (oxidized)+2 Thumb → protein disulfide isomerase II (reduced)+Thumb
    protein disulfide isomerase II (oxidized) + 2 Glutathione → protein disulfide isomerase II (reduced) + Glutathione disulfide
    ReactionCard
    Transports: Not Available
    Metabolites:
    PAMDB IDNameView
    PAMDB000048GlutathioneMetaboCard
    PAMDB001629Glutathione disulfideMetaboCard
    GO Classification:
    Process
    cell redox homeostasis
    cellular homeostasis
    cellular process
    Gene Properties
    Locus tag: PA3737
    Strand: -
    Entrez Gene ID: 880330
    Accession: NP_252426.1
    GI: 15598932
    Sequence start: 4189761
    Sequence End: 4190489
    Sequence Length: 728
    Gene Sequence: 
    >PA3737
ATGCGCGTGACCCGTTTTCTGGCTGCTGCCGCCCTCGGCCTGATGAGTACCCTGGCCCTGGCAGACAATGCCGATCAGAACATCCGCAAGACCCTGCAGGCCCTGCAACCGGACCTGCCCATCGACTCCATCGCCAGCAGCCCGCTGCAGGGGCTCTACCAGGTGCAGCTGAAGGGCGGCCGGGTGCTCTACGCCAGCGCCGACGGCCAGTTCGTCATGCAGGGCTACCTCTACCAGGTGAAGGACGGCAAGCCGGTCAACCTGACCGAGAAGGCCGAGAGCCAGGCGATCGCCAAGGCGATCAACGGCGTGCCCGCCAGCGAGATGGTGGTGTATCCGGCCAAGGGCCAGGCCAAGGCGCACATCACGGTGTTCACCGATACCACCTGCCCGTACTGCCAGAAGCTGCATGCCGAGGTGCCGGACCTGACCGAGCAGGGGATCGAGGTGCGCTACATGGCGTTCCCGCGGCAGGGGCCGCAGTCGGCGGGCGACAAGCAACTGCAGGCGGTCTGGTGTGCGAAGGAGCCGACCAAGGCGATGGACGCCATGATGAACGGCAAGGAGATCAAGTCTTCCGAGTGCAAGAACCCGGTCGACAAGCAGTTCCAGATGGGCCAGATGGTCGGGGTGCAGGGAACGCCGGCGATCGTCCTTGCCAACGGCCAGTTGCTCCCCGGCTACCAGCCGGCCAAGCAGTTGGCCAAGCTGGCGCTGGAGGCCAAATAG
    Protein Properties
    Protein Residues: 242
    Protein Molecular Weight: 26.1 kDa
    Protein Theoretical pI: 8.84
    Hydropathicity (GRAVY score): -0.198
    Charge at pH 7 (predicted): 4.35
    Protein Sequence: 
    >PA3737
MRVTRFLAAAALGLMSTLALADNADQNIRKTLQALQPDLPIDSIASSPLQGLYQVQLKGGRVLYASADGQFVMQGYLYQVKDGKPVNLTEKAESQAIAKAINGVPASEMVVYPAKGQAKAHITVFTDTTCPYCQKLHAEVPDLTEQGIEVRYMAFPRQGPQSAGDKQLQAVWCAKEPTKAMDAMMNGKEIKSSECKNPVDKQFQMGQMVGVQGTPAIVLANGQLLPGYQPAKQLAKLALEAK
    References
    External Links:
    Resource Link
    Genome ID: PA3737
    Entrez Gene ID: 880330
    NCBI Protein ID: 15598932
    General Reference: PaperBLAST - Find papers about PA3737 and its homologs