2-dehydro-3-deoxyphosphooctonate aldolase (PA3636)

Identification
Name: 2-dehydro-3-deoxyphosphooctonate aldolase
Synonyms:
  • 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
  • KDO-8-phosphate synthase
  • KDO 8-P synthase
  • KDOPS
  • Phospho-2-dehydro-3-deoxyoctonate aldolase
Gene Name: kdsA
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
D-Arabinose 5-phosphate + Water + Phosphoenolpyruvic acid ↔ 3-Deoxy-D-manno-octulosonate 8-phosphate + Phosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
3-Deoxy-D-manno-octulosonate 8-phosphate + Phosphate ↔ Phosphoenolpyruvic acid + D-Arabinose 5-phosphate + Water
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Thumb → Thumb+3-deoxy-D-manno-octulosonate 8-phosphate +Thumb
D-Arabinose 5-phosphate + Phosphoenolpyruvic acid + Water → Phosphate + 3-deoxy-D-manno-octulosonate 8-phosphate + 3-Deoxy-D-manno-octulosonate 8-phosphate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
D-Arabinose 5-phosphate + Water + Phosphoenolpyruvic acid ↔ 3-Deoxy-D-manno-octulosonate 8-phosphate + Phosphate
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb
Phosphoenolpyruvic acid + D-Arabinose 5-phosphate + Water → 3-Deoxy-D-manno-octulosonate 8-phosphate + Inorganic phosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0009173-Deoxy-D-manno-octulosonate 8-phosphateMetaboCard
PAMDB000821D-Arabinose 5-phosphateMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000111Phosphoenolpyruvic acidMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
3-deoxy-8-phosphooctulonate synthase activity
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
Process
biosynthetic process
metabolic process
Gene Properties
Locus tag: PA3636
Strand: -
Entrez Gene ID: 880428
Accession: NP_252326.1
GI: 15598832
Sequence start: 4070012
Sequence End: 4070857
Sequence Length: 845
Gene Sequence: 
>PA3636
ATGGCACAGAAGATCGTTCGCGTCGGCGATATCCAGATCGGCAACGACCTGCCGTTCGTGCTGTTCGGCGGCATGAACGTGCTGGAGTCGCGCGACCTGGCCATGCAGGTCTGCGAAGAATACGTACGGGTTACCGAGAAACTCGGTATCCCCTATGTGTTCAAGGCCAGCTTCGACAAGGCCAACCGTTCCTCGATCCACTCGTTCCGTGGTCCGGGCCTGGAAGAGGGAATGAAGATCTTCGAAGAGATCAAGAAGACCTTCAAGGTACCGGTCATCACCGATGTCCACGAGCCGTTCCAGGCCCAGCCGGTGGCCGAGGTCTGCGACATCATCCAGCTGCCGGCCTTCCTCTCGCGACAGACCGACCTGGTGGTGGCGATGGCCAGGACCAACGCGGTGATCAATATCAAGAAGGCCCAGTTCCTCGCGCCCCAGGAGATGAAGCACATCCTGACCAAGTGCGAGGAAGCCGGTAACGACCGCCTGATCCTCTGCGAGCGCGGCTCCTCCTTCGGTTACAACAACCTGGTGGTCGACATGCTCGGCTTCGGCATCATGAAGCAGTTCGAGTACCCGGTATTCTTCGACGTCACCCACGCCCTGCAGATGCCTGGCGGTCGCGCGGACTCCGCCGGCGGCCGGCGCGCCCAGGTCACCGACCTGGCCAAGGCCGGGCTCAGCCAGAAGCTCGCCGGGCTGTTCCTCGAGGCCCATCCGGACCCCGAGCACGCCAAGTGCGACGGTCCGTGCGCGCTGCGCCTGAACAAACTCGAAGCCTTCCTGTCCCAGCTCAAGCAACTGGACGAGCTGATCAAGAGCTTTCCTGCAATCGAGACTGCCTAG
Protein Properties
Protein Residues: 281
Protein Molecular Weight: 31.1 kDa
Protein Theoretical pI: 6.51
Hydropathicity (GRAVY score): -0.033
Charge at pH 7 (predicted): -1.74
Protein Sequence: 
>PA3636
MAQKIVRVGDIQIGNDLPFVLFGGMNVLESRDLAMQVCEEYVRVTEKLGIPYVFKASFDKANRSSIHSFRGPGLEEGMKIFEEIKKTFKVPVITDVHEPFQAQPVAEVCDIIQLPAFLSRQTDLVVAMARTNAVINIKKAQFLAPQEMKHILTKCEEAGNDRLILCERGSSFGYNNLVVDMLGFGIMKQFEYPVFFDVTHALQMPGGRADSAGGRRAQVTDLAKAGLSQKLAGLFLEAHPDPEHAKCDGPCALRLNKLEAFLSQLKQLDELIKSFPAIETA
References
External Links:
Resource Link
Genome ID: PA3636
Entrez Gene ID: 880428
NCBI Protein ID: 15598832
General Reference: PaperBLAST - Find papers about PA3636 and its homologs