Identification
Name: PTS system fructose-specific EIIBC component
Synonyms:
  • EIIBC-Fru
  • Fructose-specific phosphotransferase enzyme IIB component
  • EIII-Fru
  • PTS system fructose-specific EIIB component
  • Fructose permease IIC component
  • PTS system fructose-specific EIIC component
Gene Name: fruA
Enzyme Class:
Biological Properties
General Function: Involved in sugar:hydrogen symporter activity
Specific Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport
Cellular Location: Cell inner membrane; Multi-pass membrane protein
KEGG Pathways:
Transports:
Transport References:
  • Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590
KEGG Reactions: Not Available
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Protein N(pi)-phospho-L-histidine+D-FructoseProtein histidine+Thumb
Protein N(pi)-phospho-L-histidine + D-Fructose ↔ Protein histidine + Fructose 1-phosphate
ReactionCard
Protein EIIB N(pi)-phospho-L-histidine/cysteine+Thumbprotein EIIB+sugar phosphate
Protein EIIB N(pi)-phospho-L-histidine/cysteine + Sucrose → protein EIIB + sugar phosphate
ReactionCard
β-D-fructofuranose+PtsI - his 189 phosphorylated+ThumbThumb+PTS enzyme I
β-D-fructofuranose + PtsI - his 189 phosphorylated + D-Fructoseβ-D-fructofuranose 1-phosphate + PTS enzyme I
ReactionCard
Complex Reactions: Not Available
Transports:
Metabolites:
PAMDB IDNameView
PAMDB000167D-FructoseMetaboCard
PAMDB000243Fructose 1-phosphateMetaboCard
PAMDB000111Phosphoenolpyruvic acidMetaboCard
PAMDB000102Pyruvic acidMetaboCard
PAMDB000109SucroseMetaboCard
PAMDB006364β-D-fructofuranose 1-phosphateMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane
membrane part
Function
carbohydrate transmembrane transporter activity
cation transmembrane transporter activity
cation:sugar symporter activity
ion transmembrane transporter activity
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
solute:cation symporter activity
substrate-specific transmembrane transporter activity
sugar:hydrogen symporter activity
transmembrane transporter activity
transporter activity
Process
carbohydrate transport
establishment of localization
phosphoenolpyruvate-dependent sugar phosphotransferase system
transport
Gene Properties
Locus tag: PA3560
Strand: -
Entrez Gene ID: 879828
Accession: NP_252250.1
GI: 15598756
Sequence start: 3988838
Sequence End: 3990595
Sequence Length: 1757
Gene Sequence:
>PA3560
ATGAAACTAGCGATCGTCACCGCCTGCCCTGGCGGACAGGTCACCAGCGTGCTCGCCGCGCGCCTGCTGCGGGGCGCCGCCGAGCGCCTGGGCTGGGAAACCTGCGTCGAGGCGAATGCCGGGTCGAGGCCCGAGGGCGAACTGAGCGCCGAACAGATCGCCGAAGCCGACTGGGTCCTGCTGGTCGGCGTCGAGCCGCTGGCGGCGGCGCGTTTCGTCGGCAAGCCGGTGTATCGCGCGCGTCCCGCCGAGGCGCTGGCCGATCCGCGCGCCTTCCTCCAGCGGGCCGCCGCCCTGGCGAGCGTGGAGGTCGCCGGGGACGAGGCCGGCCTGGTTGCGCCGGAGGCCGGAGCGGCACCGCGGATTGTCGCGGTGACCGCCTGTCCGACCGGCGTGGCGCACACCTTCATGGCCGCCGAGGCGTTGCAGCTCGCGGCGGGGCAACTGGGCTTCGCGTTGCAGGTCGAGACCCAGGGCTCGGTCGGCGCGCGCAACCCGCTCGACCCGGCGGACATCGCCGCCGCCGACGTGGTCCTGCTGGCCGCCGACATCGACGTGGACACGGCCCGTTTCGCCGGCAAGAAGATCTACCGTTGCGGCACCGGCGTGGCCCTCAAGCAGGCCCGCGCGACGCTCGAGCGGGCGCTGGCGGAAGGGCAGGTCGAGAGCGCGGGCGCAGCCAGCGCGGTGGTCGCCAGGGACGAGAAGCGCGGGGTGTACAAGCACCTGCTGACCGGGGTGTCGTTCATGTTGCCGATGGTGGTCGCGGGCGGCCTGCTGATCGCCCTGTCGCTGGCCTTCGGCATCGATGCCTACAAGCAGCCGGGCAGCCTGGCGGCGGTGCTGAGGACGGTCGGCGACACGGCTTTCGTCCTGATGGTGCCGATGCTCGCCGGCTACATCGCCTATTCCATCGCCGACCGCCCGGGCCTGGCGCCGGGCATGCTCGGCGGCCTGCTCGCCGGGACCCTCGGCGCCGGGTTCATCGGCGGGATAGTCGCCGGCTTCATCGCCGGCTATGCGGCGCGGGCCATCAGCCACGGGCTGAGGCTGCCGGCGAGCCTGGAAGCGCTGAAGCCGATCCTGGTCATCCCGTTGCTGGCCAGCCTGGTCACCGGCCTGCTGATGCTCTACGTGGTCGGCAAGCCGGTGGCCGGGATGCTCGCGGCACTGACCGGGTTCCTCGACGGCATGGGTACCTCCAATGCCATCCTCCTCGGCCTGCTGCTCGGCGGGATGATGTGCGTCGACCTCGGCGGACCGGTCAACAAGGCCGCCTACGCCTTTTCCGTCGGCCTGCTCTCGTCGCACAGCTACGCGCCGATGGCAGCGGTGATGGCGGCGGGCATGGTGCCGCCGATCGGCATGGGCCTGGCGACCCTGCTGGCGCGGCGCAAGTTCGCCGAGAGCGAGCGGCAGGCCGGCAAGGCAGCCTCGGTGCTGGGGCTGTGCTTCATCTCCGAAGGCGCCATCCCGTTCGCCGCCAAGGACCCGTTGCGGGTGATCCCGGCGAGCATCGCCGGCGGCGCGCTGACCGGCGCCCTGTCGATGTATTTCGGCTGCAAGTTGCAGGCGCCTCACGGCGGGTTGTTCGTGATGCTGGTGCCCAACGCGATCAACCACGCCCTGGCGTACCTGCTGGCGATCGTCGCCGGCAGCCTGCTTACCGGGCTGCTCTACGCCGTGCTCAAGCGCGGCGCCGAGCCGGGACTGGCGTTGGGGACCTCGTCCTCGCGGGAGCCGGCGGCTGGCGGATAG
Protein Properties
Protein Residues: 585
Protein Molecular Weight: 59 kDa
Protein Theoretical pI: 8.26
Hydropathicity (GRAVY score): 0.666
Charge at pH 7 (predicted): 4.23
Protein Sequence:
>PA3560
MKLAIVTACPGGQVTSVLAARLLRGAAERLGWETCVEANAGSRPEGELSAEQIAEADWVLLVGVEPLAAARFVGKPVYRARPAEALADPRAFLQRAAALASVEVAGDEAGLVAPEAGAAPRIVAVTACPTGVAHTFMAAEALQLAAGQLGFALQVETQGSVGARNPLDPADIAAADVVLLAADIDVDTARFAGKKIYRCGTGVALKQARATLERALAEGQVESAGAASAVVARDEKRGVYKHLLTGVSFMLPMVVAGGLLIALSLAFGIDAYKQPGSLAAVLRTVGDTAFVLMVPMLAGYIAYSIADRPGLAPGMLGGLLAGTLGAGFIGGIVAGFIAGYAARAISHGLRLPASLEALKPILVIPLLASLVTGLLMLYVVGKPVAGMLAALTGFLDGMGTSNAILLGLLLGGMMCVDLGGPVNKAAYAFSVGLLSSHSYAPMAAVMAAGMVPPIGMGLATLLARRKFAESERQAGKAASVLGLCFISEGAIPFAAKDPLRVIPASIAGGALTGALSMYFGCKLQAPHGGLFVMLVPNAINHALAYLLAIVAGSLLTGLLYAVLKRGAEPGLALGTSSSREPAAGG
References
External Links:
Resource Link
Genome ID: PA3560
Entrez Gene ID: 879828
NCBI Protein ID: 15598756
General Reference: PaperBLAST - Find papers about PA3560 and its homologs