Dihydroorotase (PA3527)

Identification
Name: Dihydroorotase
Synonyms:
  • DHOase
Gene Name: pyrC
Enzyme Class:
Biological Properties
General Function: Involved in hydrolase activity
Specific Function: (S)-dihydroorotate + H(2)O = N-carbamoyl-L- aspartate
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
4,5-Dihydroorotic acid + Water ↔ Ureidosuccinic acid + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb
4,5-Dihydroorotic acid + Water ↔ Ureidosuccinic acid
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+4,5-Dihydroorotic acid+Thumb
N-carbamoyl-L-aspartate + Hydrogen ion → Water + 4,5-Dihydroorotic acid + 4,5-Dihydroorotic acid
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
4,5-Dihydroorotic acid + Water ↔ Ureidosuccinic acid + Hydrogen ion
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0001474,5-Dihydroorotic acidMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB006306N-carbamoyl-L-aspartateMetaboCard
PAMDB000189Ureidosuccinic acidMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
dihydroorotase activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Process
cellular aromatic compound metabolic process
cellular metabolic process
metabolic process
nucleobase metabolic process
pyrimidine base biosynthetic process
pyrimidine base metabolic process
Gene Properties
Locus tag: PA3527
Strand: +
Entrez Gene ID: 879809
Accession: NP_252217.1
GI: 15598723
Sequence start: 3947095
Sequence End: 3948141
Sequence Length: 1046
Gene Sequence: 
>PA3527
ATGTCCGACCGTCTCACCCTCCTGCGCCCCGACGACTGGCACATTCACCTGCGTGACGGTGCCGCGCTGGCCAATACCGTCGGCGACGCCGCCCGCACCTTCGGCCGCGCCATCGTCATGCCGAACCTGGTGCCGCCGGTGCGCAACGCCGCCGAAGCCGACGCCTACCGGCAGCGCATCCTCGCCGCCCGTCCCGCCGCCAGCCGCTTCGAGCCGCTGATGGTGCTGTACCTCACCGACCGCACCAGCACCGAGGAAATCCGTACCGCCAAGGCCAGCGGCTTCGTGCATGCCGCCAAGCTCTATCCGGCAGGCGCCACCACCAACTCGGACTCTGGCGTGACCCGCATCGACAATATCTTCGAAGCGCTCGAGGCGATGGCCGAGGTCGGCATGCCGCTGCTGGTGCATGGCGAGGTGACCCGCGCCGAGGTCGACGTATTCGATCGCGAGAAGCAGTTCATCGACGAGCACCTGCGCCGGGTGGTCGAGCGCTTCCCGACCCTGAAAGTGGTCTTCGAGCACATCACCACCGGCGACGCCGCCCAGTTCGTCCGGGAAGCCCCGGCCAACGTCGGCGCGACCATTACCGCCCATCACCTGCTGTACAACCGCAACCACATGCTGGTCGGCGGTATCCGTCCGCACTTCTATTGCCTGCCGATCCTCAAGCGCAACACCCACCAGGAAGCCCTGCTGGACGCCGCGGTGAGCGGCAATCCGAAATTCTTCCTCGGCACCGACTCGGCGCCGCACGCCCGCCACGCCAAGGAAGCCGCCTGCGGTTGCGCCGGCTGCTACAGCGCCTACGCCGCCATCGAGCTGTATGCCGAGGCCTTCGAACAGCGCAATGCGCTGGACAAGCTGGAAGGCTTCGCCAGCCTGCACGGCCCGGACTTCTATGGCCTGCCGCGCAACACCGACCGGATCACCCTGGTCCGCGAGGAATGGCAGGCGCCCGCCAGCCTCCCCTTCGGCGACTTCGACGTGGTGCCGCTGCGCGCCGGAGAGACACTCCGCTGGAAACTGCTGGAGGCCGGGGCATGA
Protein Properties
Protein Residues: 348
Protein Molecular Weight: 38.4 kDa
Protein Theoretical pI: 6.63
Hydropathicity (GRAVY score): -0.16
Charge at pH 7 (predicted): -2.75
Protein Sequence: 
>PA3527
MSDRLTLLRPDDWHIHLRDGAALANTVGDAARTFGRAIVMPNLVPPVRNAAEADAYRQRILAARPAASRFEPLMVLYLTDRTSTEEIRTAKASGFVHAAKLYPAGATTNSDSGVTRIDNIFEALEAMAEVGMPLLVHGEVTRAEVDVFDREKQFIDEHLRRVVERFPTLKVVFEHITTGDAAQFVREAPANVGATITAHHLLYNRNHMLVGGIRPHFYCLPILKRNTHQEALLDAAVSGNPKFFLGTDSAPHARHAKEAACGCAGCYSAYAAIELYAEAFEQRNALDKLEGFASLHGPDFYGLPRNTDRITLVREEWQAPASLPFGDFDVVPLRAGETLRWKLLEAGA
References
External Links:
Resource Link
Genome ID: PA3527
Entrez Gene ID: 879809
NCBI Protein ID: 15598723
General Reference: PaperBLAST - Find papers about PA3527 and its homologs