UDP-N-acetylenolpyruvoylglucosamine reductase (PA2977)

Identification
Name: UDP-N-acetylenolpyruvoylglucosamine reductase
Synonyms:
  • UDP-N-acetylmuramate dehydrogenase
Gene Name: murB
Enzyme Class:
Biological Properties
General Function: Involved in flavin adenine dinucleotide binding
Specific Function: Cell wall formation
Cellular Location: Cytoplasm (Probable)
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Hydrogen ion + NADPH + UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine ↔ NADP + UDP-N-Acetylmuraminate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
UDP-N-Acetylmuraminate + NAD ↔ UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
UDP-N-Acetylmuraminate + NADP ↔ UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine + NADPH + Hydrogen ion
ReactionCard
SMPDB Reactions:
Thumb+NADPH+Thumb+Thumb → Thumb+Thumb
UDP-N-acetyl-α-D-glucosamine-enolpyruvate + NADPH + Hydrogen ion + NADPH → NADP + UDP-N-acetyl-α-D-muramate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Hydrogen ion + NADPH + UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine ↔ NADP + UDP-N-Acetylmuraminate
ReactionCard
Thumb+Thumb ← Thumb+Thumb+Thumb
NADP + UDP-N-Acetylmuraminate ← Hydrogen ion + NADPH + UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
UDP-N-Acetylmuraminate + NADP → UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine + NADPH
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
PAMDB000647UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamineMetaboCard
PAMDB006354UDP-N-acetyl-α-D-glucosamine-enolpyruvateMetaboCard
PAMDB006355UDP-N-acetyl-α-D-muramateMetaboCard
PAMDB000485UDP-N-AcetylmuraminateMetaboCard
GO Classification:
Function
adenyl nucleotide binding
binding
catalytic activity
FAD or FADH2 binding
nucleoside binding
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
purine nucleoside binding
UDP-N-acetylmuramate dehydrogenase activity
Process
aminoglycan metabolic process
carbohydrate metabolic process
glycosaminoglycan metabolic process
metabolic process
oxidation reduction
peptidoglycan biosynthetic process
peptidoglycan metabolic process
polysaccharide metabolic process
primary metabolic process
Gene Properties
Locus tag: PA2977
Strand: -
Entrez Gene ID: 880517
Accession: NP_251667.1
GI: 15598173
Sequence start: 3336212
Sequence End: 3337231
Sequence Length: 1019
Gene Sequence: 
>PA2977
GTGAGCCTGGAACTGCAAGAGCATTGCTCGCTGAAGCCCTATAACACCTTCGGCATCGACGTGCGCGCCCGCCTGCTGGCCCACGCCCGGGACGAGGCTGATGTGCGCGAGGCCCTGGCCCTGGCTCGGGAGCGTGGATTGCCGCTGCTGGTGATCGGTGGTGGCAGCAACCTGCTGCTGACCCGTGACGTCGAGGCGCTGGTTTTGCGCATGGCCAGCCAGGGGCGGCGAATTGTTTCCGATGCCGCGGATTCGGTGTTGGTCGAGGCGGAGGCGGGCGAGGCCTGGGACCCATTCGTACAATGGAGCCTGGAGCGGGGCCTGGCCGGTCTGGAAAATCTCAGCCTGATTCCCGGCACCGTGGGTGCGGCGCCGATGCAGAACATCGGCGCCTATGGCGTGGAGCTGAAGGATGTCTTCGACAGCCTGACGGCGCTGGATCGCCAGGATGGAACCCTGCGTGAGTTCGATCGCCAGGCCTGCCGTTTCGGCTACCGCGACAGCCTGTTCAAGCAGGAGCCTGATCGCTGGCTGATCCTCCGCGTGCGCCTGCGCCTGACACGGCGGGAGAGGCTGCACCTGGACTACGGGCCGGTACGCCAGCGCCTGGAGGAGGAGGGCATCGCCAGTCCGACGGCCAGGGACGTAAGCCGGGTAATCTGCGCCATTCGCCGGGAGAAGCTGCCCGACCCCGCCGTATTGGGCAATGCCGGCAGCTTCTTCAAGAACCCGCTGGTGGATGCGACGCAGGCCGAGCGCTTGCGTCAGGCCTTCCCGGATCTGGTTGGCTATCCGCAGGCGGACGGTCGGCTGAAGCTGGCTGCAGGCTGGCTCATCGACAAGGGCGGCTGGAAGGGTTTCCGCGATGGCCCGGTGGGGGTACACGCGCAGCAGGCGCTGGTCCTGGTAAACCATGGCGGCGCCACTGGTGCCCAGGTCCGGGCATTGGCCGAGCGTATCCAGGAGGACGTCCGTCGGCGTTTCGGCGTCGAATTGGAGCCTGAACCCAATCTCTACTGA
Protein Properties
Protein Residues: 339
Protein Molecular Weight: 37.6 kDa
Protein Theoretical pI: 6.69
Hydropathicity (GRAVY score): -0.258
Charge at pH 7 (predicted): -0.87
Protein Sequence: 
>PA2977
MSLELQEHCSLKPYNTFGIDVRARLLAHARDEADVREALALARERGLPLLVIGGGSNLLLTRDVEALVLRMASQGRRIVSDAADSVLVEAEAGEAWDPFVQWSLERGLAGLENLSLIPGTVGAAPMQNIGAYGVELKDVFDSLTALDRQDGTLREFDRQACRFGYRDSLFKQEPDRWLILRVRLRLTRRERLHLDYGPVRQRLEEEGIASPTARDVSRVICAIRREKLPDPAVLGNAGSFFKNPLVDATQAERLRQAFPDLVGYPQADGRLKLAAGWLIDKGGWKGFRDGPVGVHAQQALVLVNHGGATGAQVRALAERIQEDVRRRFGVELEPEPNLY
References
External Links:
Resource Link
Genome ID: PA2977
Entrez Gene ID: 880517
NCBI Protein ID: 15598173
General Reference: PaperBLAST - Find papers about PA2977 and its homologs