Arsenate reductase (PA2279)

Identification
Name: Arsenate reductase
Synonyms:
  • Arsenical pump modifier
Gene Name: arsC
Enzyme Class:
Biological Properties
General Function: Involved in arsenate reductase (glutaredoxin) activity
Specific Function: Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance
Cellular Location: Not Available
KEGG Pathways: Not Available
KEGG Reactions:
Thumb+Glutaredoxin ↔ Thumb+Glutaredoxin disulfide+Thumb
Arsenate ion + Glutaredoxin ↔ Arsenite + Glutaredoxin disulfide + Water
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+glutaredoxin → Thumb+glutaredoxin disulfide+Thumb
Arsenate + glutaredoxin → Arsenite + glutaredoxin disulfide + Water
ReactionCard
Thumb+Glutaredoxin ↔ Thumb+Glutaredoxin disulfide+Thumb
Arsenate ion + Glutaredoxin ↔ Arsenite + Glutaredoxin disulfide + Water
ReactionCard
Complex Reactions:
Thumb+2 Thumb → Thumb+Thumb+Thumb
Arsenate + 2 Glutathione → Arsenite + Glutathione disulfide + Water
ReactionCard
Thumb+glutaredoxin → Thumb+glutaredoxin disulfide+Thumb
Arsenate + glutaredoxin → Arsenite + glutaredoxin disulfide + Water
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB001789ArsenateMetaboCard
PAMDB001712ArseniteMetaboCard
PAMDB000048GlutathioneMetaboCard
PAMDB001629Glutathione disulfideMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
arsenate reductase (glutaredoxin) activity
arsenate reductase activity
catalytic activity
oxidoreductase activity
Process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA2279
Strand: +
Entrez Gene ID: 877604
Accession: NP_250969.1
GI: 15597475
Sequence start: 2508293
Sequence End: 2508763
Sequence Length: 470
Gene Sequence: 
>PA2279
ATGCGAGTCCTGTTCATGTGCACGGCCAACAGTTGCCGCAGCATTCTTTCCGAAGCCATGTTCAACCACCTGGCCCCGCCGGGTTTCGAGGCATGCAGCGCCGGCAGCCAGCCCAGCGGGCGGGTGCATCCGCGCAGCCTGGCGACCCTCGAACAGGCCGGCATCGCCACCCACGGCCTGTACAGCAAGGGCAGCGAAGCCTTCGAAGGCGCACCACCGGACATCGTCATCACCGTTTGCGACGCCGCCGCGGGGGAAGCCTGCCCGCTGTATCTCGGCGCAGCGCTGAAGGCCCATTGGGGCCTGGCCGATCCCTCCGCCCTGGATGGCGACGAAGCCCTGCGGGATGCGGCGTTCCACGCCACCCTGGCACGCATCGAACAGCGTTGCCGAGCCTTCCTCGGCCTGCCCTTCGCTACCCTGGATCGCGACCAGCTCAAGCGTGAGCTGGAGCGCATCGGCTCGCTCTGA
Protein Properties
Protein Residues: 156
Protein Molecular Weight: 16.6 kDa
Protein Theoretical pI: 5.99
Hydropathicity (GRAVY score): 0.037
Charge at pH 7 (predicted): -2.99
Protein Sequence: 
>PA2279
MRVLFMCTANSCRSILSEAMFNHLAPPGFEACSAGSQPSGRVHPRSLATLEQAGIATHGLYSKGSEAFEGAPPDIVITVCDAAAGEACPLYLGAALKAHWGLADPSALDGDEALRDAAFHATLARIEQRCRAFLGLPFATLDRDQLKRELERIGSL
References
External Links:
Resource Link
Genome ID: PA2279
Entrez Gene ID: 877604
NCBI Protein ID: 15597475
General Reference: PaperBLAST - Find papers about PA2279 and its homologs