Na(+)/H(+) antiporter nhaB (PA1820)

Identification
Name: Na(+)/H(+) antiporter nhaB
Synonyms:
  • Sodium/proton antiporter nhaB
Gene Name: nhaB
Enzyme Class: Not Available
Biological Properties
General Function: Involved in sodium:hydrogen antiporter activity
Specific Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 3 H(+) per 2 Na(+). Has a high affinity for sodium, but can also transport lithium. Activity is weakly pH-dependent. Essential for regulation of intracellular pH under alkaline conditions
Cellular Location: Cell inner membrane; Multi-pass membrane protein
KEGG Pathways:
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Complex Reactions: Not Available
    Transports:
    Metabolites:
    PAMDB IDNameView
    PAMDB001633Hydrogen ionMetaboCard
    PAMDB000470SodiumMetaboCard
    GO Classification:
    Component
    cell part
    integral to membrane
    intrinsic to membrane
    membrane part
    Function
    cation transmembrane transporter activity
    hydrogen ion transmembrane transporter activity
    inorganic cation transmembrane transporter activity
    ion transmembrane transporter activity
    monovalent cation:hydrogen antiporter activity
    monovalent inorganic cation transmembrane transporter activity
    sodium:hydrogen antiporter activity
    substrate-specific transmembrane transporter activity
    transmembrane transporter activity
    transporter activity
    Process
    cation transport
    establishment of localization
    ion transport
    monovalent inorganic cation transport
    sodium ion transport
    transport
    Gene Properties
    Locus tag: PA1820
    Strand: -
    Entrez Gene ID: 877826
    Accession: NP_250511.1
    GI: 15597017
    Sequence start: 1978439
    Sequence End: 1979941
    Sequence Length: 1502
    Gene Sequence: 
    >PA1820
GTGAGCAGTCCCCTGAGCCAGGCTTTCGCACAGAACTTCCTCGGGCATTCGCCGCGCTGGTACAAGCTGACGGTGCTCGCCTTCCTCTTGCTCAACCCCCTGCTGCTATGGCTGGCCGGGCCGGTGACAAGCGCCTGGGTGCTGGTCGGCGAGTTCATCTTCACCCTGGCCATGGCGCTGAAATGCTATCCGCTACAGCCGGGTGGCCTGTTGGTGCTGGAGGCGCTGCTGCTTGGCCTGGCTACCCCCGAGGCGCTCTATGCGGAATTGCAGCACAACTTCCCGGTGCTCCTGCTGCTGATGTTCATGGTCGCCGGCATCTACTTCATGAAGGACCTGCTGCTCCTGCTGTTTTCCCGCCTGCTGCTCGGCGTGCGCTCGAAGACCCTGCTATCGCTCCTGTTCTGCCTGCTGGCCGCCCTCCTCTCGGCCTTCCTCGACGCCCTCACCGTGACCGCCGTGGTGATCAGCGTGGCGGTGGCATTCTTCGCCGTGTATCACCGGGTCGCTTCGGGGCAGCGCGCCAGCGAGGACTACGATCCCGCCACCGACCGCCAGGTCCCCGAGCTGCACCGGGCCCATCTCGAGGAATTCCGCGCCTTCCTCCGCAGCCTGCTCATGCACGCGGCGGTCGGCACCGCGCTGGGCGGCGTCTGCACCCTGGTGGGAGAGCCGCAGAACCTGCTGATCGGCCACGAGGCCGGCTGGCATTTCGTCGAGTTCTTCCGCCAGGTCGCGCCGGTATCCATGCCGGTACTGGCGGCCGGCCTGCTGACCTGCGTGCTGCTGGAGAAGAGCCGCCGCTTCGGCTATGGCGCCCAGTTGCCGGCGGCGGTGCGCCAGGTGCTCGCCGAGTACGCCGCCAGCGAAAGCCGCAAACGCGGAGCGCAGCAGAAGGCCGCGCTGCTGGTGCAGGCCCTGGCGGCGCTGGTACTGATCGTCGGGCTGGCCCTGCATGTCGCCGAGGTCGGCCTGATCGGCCTGTTGGTGATCGTGCTGATCACTGCCTTCACCGGCGTCACCGACGAACACCAGATCGGCCGCGCCTTCCAGGAGGCCCTGCCGTTCACTGCGCTGCTGGTGGTGTTCTTCGCGGTGGTCGCGGTGATCCACCAGCAGCACCTGTTCACCCCGATCATCCAGGCGGTGCTGGCGCTGCCGGCGGAACGCCAGCCGGGCATGCTGTTCATCGCCAACGGCCTGCTCTCGGCGATCAGCGACAACGTATTCGTCGCCACCATCTACATCACCGAGGTGAAACAGGCGCTGGATGCCGGCCACATGAGCCGCGAGCATTTCGATACCCTGGCGGTGGCGATCAATACCGGCACCAACCTGCCCAGCGTAGCGACGCCCAACGGCCAGGCGGCGTTCCTCTTCCTGCTGACCTCCTCCATCGCCCCGCTGGTGCGCCTGTCGTACGGCCGCATGGTCTGGATGGCGCTACCCTACACCCTGGTGATGGGCGGCCTGGGCTGGTGGGCGGTCAGTCATTGGCTTTGA
    Protein Properties
    Protein Residues: 500
    Protein Molecular Weight: 54.2 kDa
    Protein Theoretical pI: 7.48
    Hydropathicity (GRAVY score): 0.806
    Charge at pH 7 (predicted): 2.48
    Protein Sequence: 
    >PA1820
MSSPLSQAFAQNFLGHSPRWYKLTVLAFLLLNPLLLWLAGPVTSAWVLVGEFIFTLAMALKCYPLQPGGLLVLEALLLGLATPEALYAELQHNFPVLLLLMFMVAGIYFMKDLLLLLFSRLLLGVRSKTLLSLLFCLLAALLSAFLDALTVTAVVISVAVAFFAVYHRVASGQRASEDYDPATDRQVPELHRAHLEEFRAFLRSLLMHAAVGTALGGVCTLVGEPQNLLIGHEAGWHFVEFFRQVAPVSMPVLAAGLLTCVLLEKSRRFGYGAQLPAAVRQVLAEYAASESRKRGAQQKAALLVQALAALVLIVGLALHVAEVGLIGLLVIVLITAFTGVTDEHQIGRAFQEALPFTALLVVFFAVVAVIHQQHLFTPIIQAVLALPAERQPGMLFIANGLLSAISDNVFVATIYITEVKQALDAGHMSREHFDTLAVAINTGTNLPSVATPNGQAAFLFLLTSSIAPLVRLSYGRMVWMALPYTLVMGGLGWWAVSHWL
    References
    External Links:
    Resource Link
    Genome ID: PA1820
    Entrez Gene ID: 877826
    NCBI Protein ID: 15597017
    General Reference: PaperBLAST - Find papers about PA1820 and its homologs