Guanine deaminase (PA1521)

Identification
Name: Guanine deaminase
Synonyms:
  • Guanase
  • Guanine aminase
  • Guanine aminohydrolase
  • GAH
Gene Name: guaD
Enzyme Class:
Biological Properties
General Function: Involved in hydrolase activity
Specific Function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Guanine + Water ↔ Xanthine + Ammonia
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Thumb+Thumb → Thumb+Thumb
Guanine + Water → Xanthine + Ammonia
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SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Guanine + Water ↔ Xanthine + Ammonia
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Thumb+Thumb → Thumb+Thumb
Water + Guanine → Ammonia + Xanthine
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Thumb+Thumb → Thumb+Thumb
Guanine + Water → Xanthine + Ammonia
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Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb
Guanine + Hydrogen ion + Water → Ammonium + Xanthine
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000017AmmoniaMetaboCard
PAMDB001595AmmoniumMetaboCard
PAMDB000051GuanineMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000142WaterMetaboCard
PAMDB000121XanthineMetaboCard
GO Classification:
Function
binding
catalytic activity
cation binding
guanine deaminase activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
ion binding
metal ion binding
transition metal ion binding
zinc ion binding
Gene Properties
Locus tag: PA1521
Strand: -
Entrez Gene ID: 883114
Accession: NP_250212.1
GI: 15596718
Sequence start: 1653106
Sequence End: 1654410
Sequence Length: 1304
Gene Sequence: 
>PA1521
ATGACCCGCAACGCCAAAGCCTACCGCGCCGCCATCCTGCACAGCATCGCCGACCCCGCGGAGGTCGGCGTCGAACGCTCCTACGAATACTTCGAGGACGGCCTGTTGCTGGTGGAGGACGGCAAGGTCGCTCGCCTCGGTGACGCCGAAACCCTGCTCGGCGAGATCGGCGAGGTCGAGGTCTTCGAGTACCGCGACGCGCTGATCACCCCCGGCTTCATCGATACCCACATCCATTTCCCGCAGACCGGGATGATCGCCTCCTACGGCGAACAACTGCTGGACTGGCTGAACACCTATACCTTCCCCACCGAGCGCCAATTCGGCGACCAGGCCCATGCCGACCAGGTCGCCGAGATCTTCCTGCAGGAACTGCTGCGCAACGGCACCACCACCGCCCTGGTCTTCGGCAGCGTGCACCGGCAATCGGTGGAATCGCTGTTCGAGGCCGCCCGGCGCCTGGACCTGCGCCTGATCGCCGGCAAGGTGATGATGGACCGCAACGCGCCGGACTACCTGACCGACACCGCCGAGAGCAGCTACCGCGACAGCAAGGCGCTGATCGAGCGCTGGCACGGCCAGGGCCGTCTGCTCTACGCGGTGACCCCGCGCTTCGCCCCGACCAGCACCGCGGAACAGCTGGACATGGCGGCGCGGCTGCTGCGCGAGCATCCCGGCGTATACCTGCACACCCATCTGTCGGAGAACCTCAAGGAAATCGAGTGGGTGAAGGAGCTGTTCCCCGAGCGCAGCGGCTACCTGGACGTCTACGACCACCACGGCCTGCTCGGGCCGCGCTCGGTGTTCGCCCATGGCGTGCACCTGTGCGACGGCGAATGCCAGCGCCTGGCGGAGACTGGCTCGGCGGTGGCGTTCTGCCCGACCTCCAACCTGTTCCTCGGCAGCGGTCTGTTCGACCTGCCGAAGCTGGAGCGCTACAAGGTCAAGGTCGGCCTCGGCACCGATGTCGGCGCCGGCACCAGCTTCTCCCAGCTGCAGTCCCTGAACGAGGCGTACAAGGTCATGCAGTTGCAGGGCGCCCGCCTCGATCCGTTCAAGTCGCTCTACCTCGCCACCCTCGGCGGCGCCCGTGCGCTGGAGCTGGACGACCGGATCGGCAGCTTCGCCACCAGCAACGAGGCGGACTTCGTGGTCCTCGACTACCACGCCACCCCGCTGCTCTCCTACCGCCTGAGCCAGGCCGGCAGCCTGGCCGAACGGCTGTTCGCGCTGACCATCCTCGGCGACGACCGCACGGTGAAGGAAACCTTCGCCGCCGGTCGCTCGGTGCATCGCCGCGACTGA
Protein Properties
Protein Residues: 434
Protein Molecular Weight: 48.3 kDa
Protein Theoretical pI: 5.21
Hydropathicity (GRAVY score): -0.198
Charge at pH 7 (predicted): -14.46
Protein Sequence: 
>PA1521
MTRNAKAYRAAILHSIADPAEVGVERSYEYFEDGLLLVEDGKVARLGDAETLLGEIGEVEVFEYRDALITPGFIDTHIHFPQTGMIASYGEQLLDWLNTYTFPTERQFGDQAHADQVAEIFLQELLRNGTTTALVFGSVHRQSVESLFEAARRLDLRLIAGKVMMDRNAPDYLTDTAESSYRDSKALIERWHGQGRLLYAVTPRFAPTSTAEQLDMAARLLREHPGVYLHTHLSENLKEIEWVKELFPERSGYLDVYDHHGLLGPRSVFAHGVHLCDGECQRLAETGSAVAFCPTSNLFLGSGLFDLPKLERYKVKVGLGTDVGAGTSFSQLQSLNEAYKVMQLQGARLDPFKSLYLATLGGARALELDDRIGSFATSNEADFVVLDYHATPLLSYRLSQAGSLAERLFALTILGDDRTVKETFAAGRSVHRRD
References
External Links:
Resource Link
Genome ID: PA1521
Entrez Gene ID: 883114
NCBI Protein ID: 15596718
General Reference: PaperBLAST - Find papers about PA1521 and its homologs