2-hydroxy-3-oxopropionate reductase_ (PA1500)

Identification
Name: 2-hydroxy-3-oxopropionate reductase_
Synonyms:
  • Tartronate semialdehyde reductase
  • TSAR
Gene Name: glxR
Enzyme Class:
Biological Properties
General Function: Involved in 3-hydroxyisobutyrate dehydrogenase activity
Specific Function: (R)-glycerate + NAD(P)(+) = 2-hydroxy-3- oxopropanoate + NAD(P)H
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Tartronate semialdehyde + Hydrogen ion + NADH ↔ Glyceric acid + NAD
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Glyceric acid + NAD ↔ Tartronate semialdehyde + NADH + Hydrogen ion
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Glyceric acid + NADP ↔ Tartronate semialdehyde + NADPH + Hydrogen ion
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Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Glyceric acid + NAD + NADP ↔ Tartronate semialdehyde + NADH + NADPH + Hydrogen ion
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SMPDB Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb
Tartronate semialdehyde + NADH + Hydrogen ion → NAD + Glyceric acid
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Tartronate semialdehyde + Hydrogen ion + NADH ↔ Glyceric acid + NAD
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Glyceric acid + NAD ↔ Tartronate semialdehyde + NADH + Hydrogen ion
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Complex Reactions:
Thumb+NAD(P)(+) → Thumb+NAD(P)H
Glyceric acid + NAD(P)(+) → Tartronate semialdehyde + NAD(P)H
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000597Glyceric acidMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
PAMDB000707Tartronate semialdehydeMetaboCard
GO Classification:
Function
2-hydroxy-3-oxopropionate reductase activity
3-hydroxyisobutyrate dehydrogenase activity
binding
catalytic activity
coenzyme binding
cofactor binding
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
phosphogluconate dehydrogenase (decarboxylating) activity
Process
alcohol metabolic process
branched chain family amino acid metabolic process
cellular aldehyde metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
glucose catabolic process
glucose metabolic process
glyoxylate metabolic process
hexose metabolic process
metabolic process
monosaccharide metabolic process
oxidation reduction
pentose-phosphate shunt
small molecule metabolic process
valine metabolic process
Gene Properties
Locus tag: PA1500
Strand: -
Entrez Gene ID: 879491
Accession: NP_250191.1
GI: 15596697
Sequence start: 1629059
Sequence End: 1629949
Sequence Length: 890
Gene Sequence: 
>PA1500
ATGGCCAAGATCGGATTCATCGGCACCGGAATCATGGGCAAGCCCATGGCGCAGAACCTGCAGAAGGCCGGCCACAGCCTGTTCCTTTCCACCCACCACGACGCCGCTCCGGCCGACCTGCTGGAGGCCGGCGCCATTGCCCTGGCCAACCCGAAGGAAGTGGCCCAGGAAGCCGAGTTCATCATCGTCATGGTGCCGGACACCCCGCAGGTCGAGGATGTGCTGTTCCGCAAGGACGGTATCGCCGAAGGCGCCGGCCCGAACAAGGTGGTGATCGACATGAGTTCGATCTCCCCCACCGCCACCAAGGGCTTCGCCGAGAAGATCAAGGCTACCGGCGCGCAGTACCTGGACGCCCCGGTCTCCGGCGGCGAGGTCGGCGCCAAGGCGGCGACCCTGAGCATCATGGTCGGCGGCTGCCCGAACACCTTCGAACGCGCCCTGCCGCTGTTCCAGGCGATGGGCAAGAACATCACCCGCGTCGGCGGCAACGGCGACGGCCAGACCGCCAAGGTGGCCAACCAGATCATCGTCGCGCTGAACATCCAGGCGGTCGCCGAGGCCCTGCTGTTCGCCGCCCGCAACGGCGCCGATCCGGCCAAGGTGCGCGAGGCGCTGATGGGTGGCTTCGCCTCCTCGCGGATCCTCGAGGTACACGGCGAACGCATGGTCAAGGGCACCTTCGACCCGGGCTTCCGCATCAGCCTGCACCAGAAGGACCTAAACCTGGCCCTGGCCGGCGCCCGCGAGCTGAACCTGAACCTACCCAACACCGCCAACGCCCAGCAGGTGTTCAGCACCTGCGCGGCCATCGGCGGCAGTAACTGGGACCACTCGGCGCTGATCAAGGGCCTGGAGCACATGGCCAACTTCTCGATCCGCGACGAGTGA
Protein Properties
Protein Residues: 296
Protein Molecular Weight: 30.9 kDa
Protein Theoretical pI: 6.63
Hydropathicity (GRAVY score): 0.057
Charge at pH 7 (predicted): -1.38
Protein Sequence: 
>PA1500
MAKIGFIGTGIMGKPMAQNLQKAGHSLFLSTHHDAAPADLLEAGAIALANPKEVAQEAEFIIVMVPDTPQVEDVLFRKDGIAEGAGPNKVVIDMSSISPTATKGFAEKIKATGAQYLDAPVSGGEVGAKAATLSIMVGGCPNTFERALPLFQAMGKNITRVGGNGDGQTAKVANQIIVALNIQAVAEALLFAARNGADPAKVREALMGGFASSRILEVHGERMVKGTFDPGFRISLHQKDLNLALAGARELNLNLPNTANAQQVFSTCAAIGGSNWDHSALIKGLEHMANFSIRDE
References
External Links:
Resource Link
Genome ID: PA1500
Entrez Gene ID: 879491
NCBI Protein ID: 15596697
General Reference: PaperBLAST - Find papers about PA1500 and its homologs