Erythronate-4-phosphate dehydrogenase (PA1375)

Identification
Name: Erythronate-4-phosphate dehydrogenase
Synonyms: Not Available
Gene Name: pdxB
Enzyme Class:
Biological Properties
General Function: Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Specific Function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate
Cellular Location: Cytoplasm (Potential)
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
4-Phospho-D-erythronate + NAD ↔ Hydrogen ion + NADH + 2-Oxo-3-hydroxy-4-phosphobutanoic acid
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
4-Phospho-D-erythronate + NAD ↔ 2-Oxo-3-hydroxy-4-phosphobutanoic acid + NADH + Hydrogen ion
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
4-Phospho-D-erythronate + NAD → NADH + Hydrogen ion + 2-Oxo-3-hydroxy-4-phosphobutanoic acid
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
4-Phospho-D-erythronate + NAD ↔ Hydrogen ion + NADH + 2-Oxo-3-hydroxy-4-phosphobutanoic acid
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
4-Phospho-D-erythronate + NAD ↔ 2-Oxo-3-hydroxy-4-phosphobutanoic acid + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
4-Phospho-D-erythronate + NAD → Hydrogen ion + 2-Oxo-3-hydroxy-4-phosphobutanoic acid + NADH
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
4-Phospho-D-erythronate + NAD → 2-Oxo-3-hydroxy-4-phosphobutanoic acid + NADH
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0006902-Oxo-3-hydroxy-4-phosphobutanoic acidMetaboCard
PAMDB0009434-Phospho-D-erythronateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
4-phosphoerythronate dehydrogenase activity
binding
catalytic activity
cofactor binding
NAD or NADH binding
nucleotide binding
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Process
metabolic process
pyridoxine biosynthetic process
pyridoxine metabolic process
small molecule metabolic process
vitamin B6 metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Properties
Locus tag: PA1375
Strand: +
Entrez Gene ID: 881132
Accession: NP_250066.1
GI: 15596572
Sequence start: 1491913
Sequence End: 1493055
Sequence Length: 1142
Gene Sequence: 
>PA1375
ATGCGTATTCTCGCCGATGAAAACATTCCCGTGGTCGACGCCTTCTTCGCCGACCAGGGCTCCATTCGCCGCTTGCCCGGGCGCGCCATCGACCGCGCGGCGCTGGCCGAGGTCGACGTGCTGCTGGTGCGCTCGGTCACCGAGGTCAGCCGCGCGGCGCTGGCCGGCTCGCCGGTGCGCTTCGTCGGCACCTGCACCATCGGCACCGACCACCTCGACCTCGACTACTTCGCCGAGGCCGGCATCGCCTGGTCCAGCGCACCCGGCTGCAACGCCCGCGGGGTGGTGGACTACGTGCTCGGCTGCCTGCTGGCGATGGCCGAGGTGCGCGGCGCCGACCTGGCCGAACGCACCTATGGGGTGGTCGGCGCCGGGCAGGTCGGCGGGCGGCTGGTGGAGGTGCTGCGCGGGCTGGGCTGGAAAGTGCTGGTCTGCGATCCGCCGCGCCAGGCACGCGAGCCGGACGGCGAATTCGTCTCGCTGGAACGGCTGCTGGCCGAGGCCGACGTGATCAGCCTGCACACTCCGCTGAACCGCGACGGCGAACACCCGACCCGCCACCTGCTGGATGAGCCCCGCCTGGCCGCCCTGCGTCCCGGCACCTGGCTGGTCAACGCCAGCCGTGGCGCGGTGGTCGACAACCAGGCCCTGCGCCGCCTGCTCGAAGGCGGCGCCGACCTGGAAGTGGCGCTGGACGTCTGGGAAGGCGAACCGCAGGCCGACCCCGAACTGGCCGCGCGCTGCCTGATCGCCACGCCGCACATCGCCGGCTACAGCCTGGAAGGCAAGCTGCGCGGCACCGCACAGATCTACCAGGCCTACTGCGCCTGGCGCGGCATCGCCGAACGCGTGAGCCTGCAAGACGTGCTGCCGGAAACCTGGCTCGCCGGCCTGCAACTCAACCCCGGCTGCGACCCGGCCTGGGCGCTGGCCACGCTGTGCCGCGCGGTGTACGACCCGCGCAGCGACGACGCCGCCTTCCGCCGCAGCCTGACCGGCGACAGCGCCACCCGCCGCGCCGCCTTCGACGCCCTGCGCAAACACTACCCGCCGCGCCGCGAGATCACCGGCCTGCGCGTCGCCACCGGTGGACAGGCGGAGTTGCAGCGGGTGGTGCGGGCGCTGGGGGCGCAGTTGGTCTAG
Protein Properties
Protein Residues: 380
Protein Molecular Weight: 41 kDa
Protein Theoretical pI: 5.5
Hydropathicity (GRAVY score): -0.016
Charge at pH 7 (predicted): -5.79
Protein Sequence: 
>PA1375
MRILADENIPVVDAFFADQGSIRRLPGRAIDRAALAEVDVLLVRSVTEVSRAALAGSPVRFVGTCTIGTDHLDLDYFAEAGIAWSSAPGCNARGVVDYVLGCLLAMAEVRGADLAERTYGVVGAGQVGGRLVEVLRGLGWKVLVCDPPRQAREPDGEFVSLERLLAEADVISLHTPLNRDGEHPTRHLLDEPRLAALRPGTWLVNASRGAVVDNQALRRLLEGGADLEVALDVWEGEPQADPELAARCLIATPHIAGYSLEGKLRGTAQIYQAYCAWRGIAERVSLQDVLPETWLAGLQLNPGCDPAWALATLCRAVYDPRSDDAAFRRSLTGDSATRRAAFDALRKHYPPRREITGLRVATGGQAELQRVVRALGAQLV
References
External Links:
Resource Link
Genome ID: PA1375
Entrez Gene ID: 881132
NCBI Protein ID: 15596572
General Reference: PaperBLAST - Find papers about PA1375 and its homologs