PqsA (PA0996)

Identification
Name: PqsA
Synonyms:
  • Anthranilate-CoA ligase
Gene Name: pqsA
Enzyme Class:

6.2.1.32

Biological Properties
General Function: secondary metabolite biosynthetic process, cofactor biosynthetic process, metabolic process
Specific Function: catalytic activity
Cellular Location: Cytoplasmic Membrane
KEGG Pathways:
  • 4-hydroxy-2(1H)-quinolone biosynthesis PWY-6661
  • 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis PWY-6660
    KEGG Reactions:
    Thumb + Thumb + Thumb → Thumb + Thumb + Thumb

    Anthranilic Acid + Coenzyme A + ATP→ AMP + Anthraniloyl-CoA + Diphosphate
    ReactionCard
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Thumb
    anthranilate + ATP + coenzyme A → anthraniloyl-CoA + AMP + diphosphate
    ReactionCard
    Complex Reactions: Not Available
    Transports: Not Available
    Metabolites:
    PAMDB ID Name View
    PAMDB000262 2-Aminobenzoic acid MetaboCard
    PAMDB000148 ATP MetaboCard
    PAMDB000381 Coenzyme A MetaboCard
    PAMDB100091 Anthraniloyl-CoA MetaboCard
    PAMDB000014 AMP MetaboCard
    PAMDB000633 Pyrophosphate MetaboCard
    GO Classification:
    Function
    catalytic activity
    Process
    secondary metabolite biosynthetic process
    cofactor biosynthetic process
    metabolic process
    Gene Properties
    Locus tag: PA0996
    Strand: +
    Entrez Gene ID: 880760
    Accession: NP_249687.1
    GI: 15596193
    Sequence start: 1078462
    Sequence End: 1080015
    Sequence Length: 1554
    Gene Sequence: 
    >PA0996
ATGTCCACATTGGCCAACCTGACCGAGGTTCTGTTCCGCCTCGATTTCGATCCCGATACCGCCGTTTATCACTATCGGGGCCAGACTCTCAGCCGGCTGC AATGCCGGACCTACATTCTCTCCCAGGCCAGCCAACTGGCCCGCCTGCTCAAGCCCGGCGATCGCGTGGTGCTGGCGTTGAACGACTCGCCTTCGCTGGC CTGCCTGTTCCTGGCCTGCATCGCGGTCGGCGCCATTCCCGCCGTGATCAATCCCAAGTCCCGCGAGCAGGCCCTGGCCGATATCGCTGCCGACTGCCAG GCCAGCCTGGTGGTGCGTGAAGCCGATGCACCGTCGCTGAGCGGTCCTTTGGCGCCGTTGACCCTGCGTGCGGCCGCCGGACGCCCTTTGCTCGACGATT TCTCGCTGGACGCGCTGGTCGGCCCTGCGGACCTCGATTGGAGTGCCTTCCATCGCCAGGACCCGGCGGCAGCCTGTTTCCTGCAATACACCTCGGGTTC CACCGGGGCGCCCAAGGGGGTGATGCACAGCCTGCGCAACACGCTCGGTTTCTGCCGGGCGTTCGCTACGGAGTTGCTGGCATTGCAGGCGGGAGACCGG CTGTATTCGATTCCCAAGATGTTCTTCGGCTATGGCATGGGCAACAGCCTGTTCTTTCCCTGGTTCAGCGGAGCCTCGGCGCTGCTCGACGATACCTGGC CGAGCCCGGAGCGGGTTCTGGAGAACCTGGTCGCCTTCCGCCCCCGGGTCCTGTTTGGGGTGCCGGCCATCTATGCCTCGCTGCGTCCGCAGGCCAGGGA GCTGTTGAGCAGCGTGCGCCTGGCGTTTTCCGCCGGCTCGCCGCTGCCGCGCGGCGAGTTCGAATTCTGGGCCGCGCACGGGCTGGAGATCTGCGACGGC ATCGGGGCTACCGAGGTCGGCCATGTGTTCCTCGCCAACCGCCCGGGCCAGGCGCGTGCCGACAGCACCGGGCTGCCGTTGCCTGGCTATGAGTGCCGGC TGGTGGACCGCGAAGGACACACTATCGAGGAAGCGGGCCGGCAAGGCGTGCTGTTGGTGCGTGGCCCAGGGCTGAGTCCGGGTTACTGGCGGGCCAGCGA AGAGCAGCAGGCGCGCTTCGCAGGTGGCTGGTACCGCACCGGCGACCTGTTCGAGCGCGACGAGTCGGGTGCCTACCGTCACTGTGGGCGGGAAGACGAT CTGTTCAAGGTGAATGGCCGCTGGGTGGTGCCGACCCAGGTCGAGCAGGCGATCTGCCGTCATCTGCCGGAAGTGAGCGAGGCGGTTCTGGTTCCTACCT GCCGGCTGCACGACGGCTTGCGTCCGACCCTGTTCGTCACCCTGGCCACTCCGCTGGACGACAACCAGATCCTGCTGGCGCAGCGCATCGACCAGCATCT CGCCGAACAGATTCCCTCGCACATGCTGCCCAGCCAATTGCATGTGCTGCCGGCCTTGCCGCGCAACGACAACGGCAAGTTGGCGCGCGCCGAGCTGCGC CACCTGGCCGACACCCTTTATCACGACAACCTTCCGGAGGAACGGGCATGTTGA
    Protein Properties
    Protein Residues: 517
    Protein Molecular Weight: 56.6 kDa
    Protein Theoretical pI: 6.15
    Hydropathicity (GRAVY score): -0.068
    Charge at pH 7 (predicted): -6.98
    Protein Sequence: 
    >PA0996
MSTLANLTEVLFRLDFDPDTAVYHYRGQTLSRLQCRTYILSQASQLARLLKPGDRVVLALNDSPSLACLFLACIAVGAIPAVINPKSREQALADIAADCQ ASLVVREADAPSLSGPLAPLTLRAAAGRPLLDDFSLDALVGPADLDWSAFHRQDPAAACFLQYTSGSTGAPKGVMHSLRNTLGFCRAFATELLALQAGDR LYSIPKMFFGYGMGNSLFFPWFSGASALLDDTWPSPERVLENLVAFRPRVLFGVPAIYASLRPQARELLSSVRLAFSAGSPLPRGEFEFWAAHGLEICDG IGATEVGHVFLANRPGQARADSTGLPLPGYECRLVDREGHTIEEAGRQGVLLVRGPGLSPGYWRASEEQQARFAGGWYRTGDLFERDESGAYRHCGREDD LFKVNGRWVVPTQVEQAICRHLPEVSEAVLVPTCRLHDGLRPTLFVTLATPLDDNQILLAQRIDQHLAEQIPSHMLPSQLHVLPALPRNDNGKLARAELR HLADTLYHDNLPEERAC
    References
    External Links:
    Resource Link
    Genome ID: PA0996
    Entrez Gene ID: 880760
    NCBI Protein ID: 15596193
    General Reference: PaperBLAST - Find papers about PA0996 and its homologs