Identification
Name: N-succinylglutamate 5-semialdehyde dehydrogenase
Synonyms:
  • Succinylglutamic semialdehyde dehydrogenase
  • SGSD
Gene Name: astD
Enzyme Class:
Biological Properties
General Function: Involved in oxidoreductase activity
Specific Function: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. Also shows activity with decanal or succinic semialdehyde as the electron donor and NAD as the electron acceptor. No activity is detected with NADP as the electron acceptor. Therefore, is an aldehyde dehydrogenase with broad substrate specificity
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb2 Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb
SMPDB Reactions:
Thumb+Thumb+Thumb2 Thumb+Thumb+ N2-succinylglutamate+Thumb
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+ThumbN2-succinylglutamate+Thumb+Thumb
Complex Reactions:
Thumb+Thumb+ThumbThumb+Thumb
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB006308 N2-succinylglutamateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000387N-Succinyl-L-glutamateMetaboCard
PAMDB000287N2-Succinyl-L-glutamic acid 5-semialdehydeMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
succinylglutamate-semialdehyde dehydrogenase activity
Process
arginine catabolic process
arginine metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
glutamine family amino acid metabolic process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA0898
Strand: +
Entrez Gene ID: 883040
Accession: NP_249589.1
GI: 15596095
Sequence start: 981422
Sequence End: 982888
Sequence Length: 1466
Gene Sequence:
>PA0898
ATGATGAGTACCCATTACATTGCCGGCCAGTGGCTGGCGGGCCAGGGCGAGACCCTGGAGTCCCTCGACCCGGTTGGCCAGGGCGTGGTCTGGTCCGGGCGCGGCGCTGACGCCACCCAGGTCGACGCTGCCGTGTGCGCCGCCCGCGAGGCCTTCCCGGCCTGGGCGCGGCGCCCGCTGGAGCAGCGCATCGAGTTGCTCGAGCGCTTCGCTGCGACCCTCAAGTCCCGCGCCGACGAGCTGGCCCGAGTGATCGGCGAGGAAACCGGCAAGCCGCTGTGGGAGTCGGCCACCGAAGTGACCAGCATGGTCAACAAGGTGGCGATCTCGGTGCAGGCGTTCCGCGAGCGCACCGGCGAGAAATCCGGTCCGCTGGCCGACGCTACCGCCGTGCTACGGCACAAGCCGCATGGCGTGGTGGCGGTATTCGGTCCCTACAATTTCCCCGGCCACCTGCCCAACGGGCATATCGTCCCGGCGCTGCTGGCCGGTAACTGCGTGGTGTTCAAGCCCAGCGAGCTGACCCCGAAGGTCGCCGAGCTGACGCTCAAGGCCTGGATCCAGGCCGGCCTGCCGGCCGGCGTGCTCAACCTGGTCCAGGGCGGTCGCGAAACCGGCGTCGCGCTGGCCGCCCACCGAGGGCTCGACGGTCTGTTCTTCACCGGGTCCAGTCGCACCGGCAACCTGCTGCACAGCCAGTTTGGCGGCCAGCCGCAGAAAATCCTGGCGCTGGAGATGGGCGGCAACAACCCGCTGGTGGTGGAGGAGGTCGCCGACCTCGACGCCGCCGTCTACACCATCATCCAGTCCGCCTTCATCTCCGCAGGCCAGCGTTGCACCTGCGCCCGCCGCCTGCTGGTGCCGCAGGGCGCCTGGGGCGACGCACTGCTGGCGCGCCTGGTGGCGGTCAGCGCTACCCTGCGGGTCGGTCGCTTCGACGAACAGCCGGCGCCGTTCATGGGCGCGGTGATTTCGCTGAGCGCCGCCGAGCACCTGCTCAAGGCCCAGGAGCATTTGATCGGCAAGGGCGCACAGCCGCTGCTGGCGATGACCCAGCCGATCGACGGCGCCGCCCTGCTGACCCCGGGCATCCTCGACGTCAGCGCGGTGGCCGAGCGACCGGACGAAGAGTTCTTCGGGCCGCTGTTGCAAGTGATCCGCTACTCCGATTTCGCTGCGGCGATCCGTGAAGCCAACGCCACCCAGTACGGCCTGGCCGCCGGGTTGCTGTCGGATTCCCGCGAGCGTTTCGAGCAGTTCCTCGTGGAAAGCCGCGCCGGCATCGTCAACTGGAACAAGCAGCTCACCGGCGCCGCCAGCAGCGCGCCGTTCGGCGGTATCGGCGCGTCCGGCAACCACCGGCCGAGCGCCTACTACGCCGCCGATTACTGCGCCTATCCGGTCGCCTCGCTGGAAAGCCCCAGCGTGTCCCTTCCTGCCACCCTGACTCCCGGGATCAGCCTATGA
Protein Properties
Protein Residues: 488
Protein Molecular Weight: 51.5 kDa
Protein Theoretical pI: 6.19
Hydropathicity (GRAVY score): 0.1
Charge at pH 7 (predicted): -4.73
Protein Sequence:
>PA0898
MMSTHYIAGQWLAGQGETLESLDPVGQGVVWSGRGADATQVDAAVCAAREAFPAWARRPLEQRIELLERFAATLKSRADELARVIGEETGKPLWESATEVTSMVNKVAISVQAFRERTGEKSGPLADATAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNCVVFKPSELTPKVAELTLKAWIQAGLPAGVLNLVQGGRETGVALAAHRGLDGLFFTGSSRTGNLLHSQFGGQPQKILALEMGGNNPLVVEEVADLDAAVYTIIQSAFISAGQRCTCARRLLVPQGAWGDALLARLVAVSATLRVGRFDEQPAPFMGAVISLSAAEHLLKAQEHLIGKGAQPLLAMTQPIDGAALLTPGILDVSAVAERPDEEFFGPLLQVIRYSDFAAAIREANATQYGLAAGLLSDSRERFEQFLVESRAGIVNWNKQLTGAASSAPFGGIGASGNHRPSAYYAADYCAYPVASLESPSVSLPATLTPGISL
References
External Links:
Resource Link
Genome ID: PA0898
Entrez Gene ID: 883040
NCBI Protein ID: 15596095
General Reference: PaperBLAST - Find papers about PA0898 and its homologs