Bis(5'-nucleosyl)-tetraphosphatase [symmetrical] (PA0590)

Identification
Name: Bis(5'-nucleosyl)-tetraphosphatase [symmetrical]
Synonyms:
  • Ap4A hydrolase
  • Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
  • Diadenosine tetraphosphatase
Gene Name: apaH
Enzyme Class:
Biological Properties
General Function: Involved in bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
Specific Function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ 2 Thumb+2 Thumb
Diadenosine tetraphosphate + Water ↔ 2 ADP + 2 Hydrogen ion
ReactionCard
Thumb+Thumb ↔ 2 Thumb
Diadenosine tetraphosphate + Water ↔ 2 ADP
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ 2 Thumb+2 Thumb
Diadenosine tetraphosphate + Water ↔ 2 ADP + 2 Hydrogen ion
ReactionCard
Thumb+Thumb ↔ 2 Thumb
Diadenosine tetraphosphate + Water ↔ 2 ADP
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Thumb+Thumb → Thumb+Thumb
Water + Diadenosine tetraphosphate → Hydrogen ion + ADP
ReactionCard
Complex Reactions:
Thumb+Thumb → 2 Thumb+2 Thumb
P1,P4-Bis(5'-guanosyl) tetraphosphate + Water → 2 Guanosine diphosphate + 2 Hydrogen ion
ReactionCard
Thumb+Thumb → 2 Thumb
Diadenosine tetraphosphate + Water → 2 ADP
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000300Diadenosine tetraphosphateMetaboCard
PAMDB000296Guanosine diphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001671P1,P4-Bis(5'-guanosyl) tetraphosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
bis(5'-nucleosyl)-tetraphosphatase activity
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
nucleotide diphosphatase activity
pyrophosphatase activity
Gene Properties
Locus tag: PA0590
Strand: -
Entrez Gene ID: 880834
Accession: NP_249281.1
GI: 15595787
Sequence start: 649307
Sequence End: 650158
Sequence Length: 851
Gene Sequence: 
>PA0590
ATGGCGGTCTACGCGGTAGGCGACCTGCAGGGTTGCCTGGATCCCCTGAAATGCCTGCTGGAGCGCGTCGCCTTCGACCCGGCCAAGGACCGCCTGTGGCTGGTCGGCGACCTGGTCAACCGCGGCCCGCAGTCCCTGGAGACGCTGCGCTTCCTCTATGCCATGCGCGAGTCGGTGGTCAGCGTCCTGGGCAACCACGACCTGCACCTGCTGGCGGTAGCGCACAAGTCCGAGCGCCTGAAGAAGTCCGACACGCTGCGGGAAATCCTCGAGGCGCCGGACCGCGAGCCACTGCTCGACTGGCTGCGTCGCCTGCCGCTGCTGCACTATGACGAACAACGCAAGGTCGCCCTGGTGCATGCCGGCATCCCCCCGCAGTGGAGCCTGGAAAAAGCCCGCCTGCGCGCAGCCGAGGTGGAGCAAGCATTGCGCGACGACCAGCGCCTGCCGCTGTTCCTCGACGGCATGTACGGCAACGAGCCGGCCAAGTGGGACAAGAAGCTGCATGGCATCGATCGTCTGAGGGTGATCACCAACTACTTCACCCGCATGCGTTTCTGCACCGAAGATGGCAAGCTCGACCTGAAGAGCAAGGAAGGCCTCGACACCGCGCCGCCCGGCTACGCCCCCTGGTTCAGCTTCCCTTCGCGCAAGACCCGCGGCGAGAAGATCATCTTCGGCCACTGGGCGGCCCTCGAAGGCCACTGCGACGAGCCCGGCCTGTTCGCCCTGGATACCGGCTGCGTCTGGGGCGCGCGGATGACCCTGTTGAACGTCGACAGCGGCGAACGCCTGAGCTGCGATTGCGCCGAACAGCGCGCGCCGGCCAGACCCGCCGCCACGCCCGCATGA
Protein Properties
Protein Residues: 283
Protein Molecular Weight: 32 kDa
Protein Theoretical pI: 7.19
Hydropathicity (GRAVY score): -0.346
Charge at pH 7 (predicted): 0.72
Protein Sequence: 
>PA0590
MAVYAVGDLQGCLDPLKCLLERVAFDPAKDRLWLVGDLVNRGPQSLETLRFLYAMRESVVSVLGNHDLHLLAVAHKSERLKKSDTLREILEAPDREPLLDWLRRLPLLHYDEQRKVALVHAGIPPQWSLEKARLRAAEVEQALRDDQRLPLFLDGMYGNEPAKWDKKLHGIDRLRVITNYFTRMRFCTEDGKLDLKSKEGLDTAPPGYAPWFSFPSRKTRGEKIIFGHWAALEGHCDEPGLFALDTGCVWGARMTLLNVDSGERLSCDCAEQRAPARPAATPA
References
External Links:
Resource Link
Genome ID: PA0590
Entrez Gene ID: 880834
NCBI Protein ID: 15595787
General Reference: PaperBLAST - Find papers about PA0590 and its homologs