D-erythrose-4-phosphate dehydrogenase (PA0551)

Identification
Name: D-erythrose-4-phosphate dehydrogenase
Synonyms:
  • E4PDH
Gene Name: epd
Enzyme Class:
Biological Properties
General Function: Involved in erythrose-4-phosphate dehydrogenase activity
Specific Function: Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+2 Thumb+Thumb
D-Erythrose 4-phosphate + Water + NAD ↔ 4-Phospho-D-erythronate + 2 Hydrogen ion + NADH
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
D-Erythrose 4-phosphate + NAD + Water ↔ 4-Phospho-D-erythronate + NADH + Hydrogen ion
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
D-Erythrose 4-phosphate + NAD + Water → NADH + Hydrogen ion + 4-Phospho-D-erythronate
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+2 Thumb
D-Erythrose 4-phosphate + NAD + Water → 4-Phospho-D-erythronate + NADH + 2 Hydrogen ion
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+2 Thumb+Thumb
D-Erythrose 4-phosphate + Water + NAD ↔ 4-Phospho-D-erythronate + 2 Hydrogen ion + NADH
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb
D-Erythrose 4-phosphate + NAD + Water → 4-Phospho-D-erythronate + NADH
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0009434-Phospho-D-erythronateMetaboCard
PAMDB000460D-Erythrose 4-phosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
binding
catalytic activity
erythrose-4-phosphate dehydrogenase activity
NAD or NADH binding
nucleotide binding
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Process
cellular metabolic process
coenzyme biosynthetic process
coenzyme metabolic process
cofactor metabolic process
metabolic process
oxidation reduction
pyridoxal phosphate biosynthetic process
Gene Properties
Locus tag: PA0551
Strand: +
Entrez Gene ID: 879410
Accession: NP_249242.1
GI: 15595748
Sequence start: 610214
Sequence End: 611275
Sequence Length: 1061
Gene Sequence: 
>PA0551
ATGTCCACCCCGCCTTTTCGCGTCGCGCTCAATGGCTATGGCCGTATCGGCCGCTGCGTCCTGCGCGCGCTGCACGAGCGCCCGGAGCAACTGGGCTTCGAGATCGTCGCGCTGAACGACCTGGCCGACCAGGCCAGCGTCGAGTACCTGACCCGCTTCGACTCCACCCATGGCCGCTTTCCCGGCGAAGTGAAGGTCGACGGCGACTGCCTGCACATCAACGGCGATTGCGTGAAGGTGCTGCGCAGCCCGACTCCGGAGGCCATCGACTGGCAGGCGCTGCGGGTCGACCTGGTGCTGGAGTGCTCCGGCCAGTACACCAACCGCGCCCAGGCCGAGCGTTTCCTCCGCGCCGGCGCGCCGCGGGTGCTGTTCTCGCAGCCGATGGCGAGCGAGGCGGACATCGACGCCACCATCGTCTATGGGGTCAACCAGCAGGACCTCAGCGGCCGCGAAACGCTGGTCTCCAACGCCTCCTGCACGACCAATTGCGGGGTGCCGCTGCTCAAGCTGCTGAACGAGGCGATCGGCCTGGAATACGTGTCGATCACCACCATCCACTCGGCGATGAACGACCAGCCGGTGATCGACGCCTACCACCATGAGGACCTGCGCCGTACCCGTTCGGCGTTCCAGTCGGTGATCCCGGTGTCCACCGGTCTGGCGCGCGGCATCGAACGCCTGTTGCCGGAACTTGCCGGGCGCATCCAGGCCAAAGCCATACGCGTGCCCACGGTGAACGTCTCGGCGCTGGACATCACCCTGCAGACTTCCCGCGACACCTCCGCCGCCGAGATCAACCGGGTGCTTCGCGAGGCTGCCGAAAGCGGCCCGCTGCGCGGACTGCTGGCTTATACCGAGCTGCCGCACGCCAGTTGCGATTTCAACCACGACCCCCATTCGGCCATCGTCGATGGCAGCCAGACCCGCGTTTCCGGGCCTCGCCTGGTCAACTTGCTGGCCTGGTTCGACAACGAATGGGGATTCGCCAACCGTATGCTCGACGTCGCCGGACACTACCTGCGCGCCGCCGTGCCTGATCAACAAGTACCCAAGGACTGA
Protein Properties
Protein Residues: 353
Protein Molecular Weight: 38.7 kDa
Protein Theoretical pI: 5.8
Hydropathicity (GRAVY score): -0.174
Charge at pH 7 (predicted): -6.8
Protein Sequence: 
>PA0551
MSTPPFRVALNGYGRIGRCVLRALHERPEQLGFEIVALNDLADQASVEYLTRFDSTHGRFPGEVKVDGDCLHINGDCVKVLRSPTPEAIDWQALRVDLVLECSGQYTNRAQAERFLRAGAPRVLFSQPMASEADIDATIVYGVNQQDLSGRETLVSNASCTTNCGVPLLKLLNEAIGLEYVSITTIHSAMNDQPVIDAYHHEDLRRTRSAFQSVIPVSTGLARGIERLLPELAGRIQAKAIRVPTVNVSALDITLQTSRDTSAAEINRVLREAAESGPLRGLLAYTELPHASCDFNHDPHSAIVDGSQTRVSGPRLVNLLAWFDNEWGFANRMLDVAGHYLRAAVPDQQVPKD
References
External Links:
Resource Link
Genome ID: PA0551
Entrez Gene ID: 879410
NCBI Protein ID: 15595748
General Reference: PaperBLAST - Find papers about PA0551 and its homologs