Identification |
Name: |
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase |
Synonyms: |
- 7,8-diamino-pelargonic acid aminotransferase
- DAPA AT
- DAPA aminotransferase
- Diaminopelargonic acid synthase
|
Gene Name: |
bioA |
Enzyme Class: |
|
Biological Properties |
General Function: |
Involved in transaminase activity |
Specific Function: |
Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor |
Cellular Location: |
Cytoplasm |
KEGG Pathways: |
|
KEGG Reactions: |
|
SMPDB Reactions: |
|
![Thumb](/molecules/PAMDB000959thumb.png) | + | S-adenosyl-L-methionine | → | ![Thumb](/molecules/PAMDB006303thumb.png) | + | 7,8-Diaminononanoate | + | ![Thumb](/molecules/PAMDB000957thumb.png) |
| |
|
PseudoCyc/BioCyc Reactions: |
|
Complex Reactions: |
Not Available |
Transports: |
Not Available |
Metabolites: |
PAMDB ID | Name | View |
---|
PAMDB000957 | 7,8-Diaminononanoate | MetaboCard | PAMDB000959 | 8-Amino-7-oxononanoate | MetaboCard | PAMDB006303 | a sulfurated [sulfur carrier] | MetaboCard | PAMDB001688 | S-Adenosyl-4-methylthio-2-oxobutanoate | MetaboCard | PAMDB000289 | S-Adenosylmethionine | MetaboCard |
|
GO Classification: |
Function |
---|
adenosylmethionine-8-amino-7-oxononanoate transaminase activity | binding | catalytic activity | cofactor binding | pyridoxal phosphate binding | transaminase activity | transferase activity | transferase activity, transferring nitrogenous groups | Process |
---|
biotin biosynthetic process | biotin metabolic process | metabolic process | small molecule metabolic process | vitamin metabolic process | water-soluble vitamin metabolic process |
|
Gene Properties |
Locus tag: |
PA0420 |
Strand: |
- |
Entrez Gene ID: |
878017 |
Accession: |
NP_249111.1 |
GI: |
15595617 |
Sequence start: |
466833 |
Sequence End: |
468236 |
Sequence Length: |
1403 |
Gene Sequence: |
>PA0420
ATGGGCCTTAACGCCGACTGGATGCAGCGCGACCTGAACGTACTCTGGCATCCCTGTACCCAGATGAAAGACCACGAACGCCTGCCGGTGATCCCGATCCGCCGCGGCGAAGGCGTCTGGCTGGAGGATTTCGAAGGCAAGCGCTACATCGACGCGGTCAGTTCCTGGTGGGTCAATGTGTTCGGTCACGCCAACCCGCGCATCAACCAGCGCATCAAGGACCAGGTCGACCAGTTGGAGCACGTGATCCTCGCCGGATTCAGCCACCAGCCGGTGATCGAGCTGTCGGAGCGACTGGTGAAAATCACCCCGCCGGGGCTCGACCGGGTGTTCTACGCCGACAGCGGCTCGGCGGGCATCGAGGTCGCGCTGAAGATGAGCTACCACTTCTGGCTCAATAGCGGCAGGCCGCGCAAGAAGCGCTTCGTCACCCTGACCAACAGCTACCACGGCGAAACCATCGCGGCGATGTCGGTGGGCGACGTGGCGCTGTTCACCGAAACCTACAAGTCGCTGCTGCTGGACACCATCAAGGTGCCCAGCCCGGACTGCTTTCTGCGTCCGGACGGCATGTGCTGGGAAGAACATTCGCGGAACATGTTCGCCCACATGGAGCGCACCCTGGCCGAAGGGCACGACGAGATCGCCGCGGTCATCGTCGAACCGCTGATCCAGGGCGCCGGCGGCATGCGCATGTACCATCCGGTCTACCTCAAGCTGCTGCGCGAAGCCTGCGACCGCTATGGCGTGCACCTGATCCACGACGAGATCGCGGTGGGCTTCGGCCGCACCGGGACGATGTTCGCCTGCGAGCAGGCCGGCATCGCCCCGGATTTCCTCTGCCTGTCCAAGGCCCTCACCGGCGGCTACCTGCCGATGTCCGCGGTGCTGACCAGCGAGACCATCTACCGGGGCTTCTACGACGACTACCAGACCCTGCGCGCCTTCCTCCACTCGCACACCTATACCGGCAACCCGCTGGCCTGCGCCGCCGCCCTGGCGACCCTGGACATCTTCGAGGAAGACAAGGTGATCGAGGCCAACCGCGCGCTGTCCACCCACATGGCCAGGGCCACCGCGCACCTGGCCGACCACCCGCATGTCGCCGAGGTGCGCCAGACCGGGATGGTCCTGGCCATCGAAATGGTCCAGGACAAGGCGTCCAGGACGCCCTACCCCTGGCAGGAGCGCCGCGGCCTGAAGGTCTTCCAGCATGGCCTGGAGCGCGGCGCGCTGCTGCGCCCGCTGGGCAGCGTGGTGTATTTCCTGCCGCCCTACGTGATTACCCCGGAGCAGATCGACTTCCTCGCCGAGGTGGCCAGCGAAGGCATCGACATCGCCACCCGCGACGCGGTCAGCGTGGCGGTCAGCGACTTCCACCCGGACCACCGCGATCCGGGCTGA |
Protein Properties |
Protein Residues: |
467 |
Protein Molecular Weight: |
52.5 kDa |
Protein Theoretical pI: |
6.28 |
Hydropathicity (GRAVY score): |
-0.146 |
Charge at pH 7 (predicted): |
-8.91 |
Protein Sequence: |
>PA0420
MGLNADWMQRDLNVLWHPCTQMKDHERLPVIPIRRGEGVWLEDFEGKRYIDAVSSWWVNVFGHANPRINQRIKDQVDQLEHVILAGFSHQPVIELSERLVKITPPGLDRVFYADSGSAGIEVALKMSYHFWLNSGRPRKKRFVTLTNSYHGETIAAMSVGDVALFTETYKSLLLDTIKVPSPDCFLRPDGMCWEEHSRNMFAHMERTLAEGHDEIAAVIVEPLIQGAGGMRMYHPVYLKLLREACDRYGVHLIHDEIAVGFGRTGTMFACEQAGIAPDFLCLSKALTGGYLPMSAVLTSETIYRGFYDDYQTLRAFLHSHTYTGNPLACAAALATLDIFEEDKVIEANRALSTHMARATAHLADHPHVAEVRQTGMVLAIEMVQDKASRTPYPWQERRGLKVFQHGLERGALLRPLGSVVYFLPPYVITPEQIDFLAEVASEGIDIATRDAVSVAVSDFHPDHRDPG |
References |
External Links: |
|
General Reference: |
PaperBLAST - Find papers about PA0420 and its homologs
|