Identification |
Name: |
Dihydroxy-acid dehydratase |
Synonyms: |
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Gene Name: |
ilvD |
Enzyme Class: |
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Biological Properties |
General Function: |
Involved in metabolic process |
Specific Function: |
2,3-dihydroxy-3-methylbutanoate = 3-methyl-2- oxobutanoate + H(2)O |
Cellular Location: |
Not Available |
KEGG Pathways: |
- Metabolic pathways pae01100
- Pantothenate and CoA biosynthesis pae00770
- Valine, leucine and isoleucine biosynthesis pae00290
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KEGG Reactions: |
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SMPDB Reactions: |
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| → | | + | 3-Methyl-2-oxovaleric acid | + | |
| | | |
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PseudoCyc/BioCyc Reactions: |
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Complex Reactions: |
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Transports: |
Not Available |
Metabolites: |
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GO Classification: |
Function |
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carbon-oxygen lyase activity | catalytic activity | dihydroxy-acid dehydratase activity | hydro-lyase activity | lyase activity | Process |
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branched chain family amino acid biosynthetic process | cellular amino acid and derivative metabolic process | cellular amino acid biosynthetic process | cellular amino acid metabolic process | cellular metabolic process | metabolic process |
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Gene Properties |
Locus tag: |
PA0353 |
Strand: |
- |
Entrez Gene ID: |
879274 |
Accession: |
NP_249044.1 |
GI: |
15595550 |
Sequence start: |
396057 |
Sequence End: |
397895 |
Sequence Length: |
1838 |
Gene Sequence: |
>PA0353
ATGCCCGATTACCGCTCGAAAACCTCCACCCACGGCCGCAACATGGCCGGCGCCCGCGCCCTCTGGCGCGCCACCGGGATGAAGGACGAAGACTTCAAGAAGCCGATCATCGCCATCGCCAACTCCTTCACCCAGTTCGTGCCCGGCCACGTGCACCTGAAGGACCTCGGCCAACTGGTCGCCCGCGAGATCGAGAAGGCCGGCGGCGTGGCCAAGGAATTCAACACCATCGCCGTCGACGACGGCATCGCCATGGGCCACGACGGCATGCTCTATTCGCTGCCGAGCCGGGAGATCATCGCCGACTCCGTGGAATACATGGTCAACGCCCACTGCGCCGACGCCATCGTCTGCATCTCCAACTGCGACAAGATCACCCCCGGCATGCTGATGGCCGCGCTGCGCCTGAACATCCCGGTAGTGTTCGTCTCCGGCGGGCCGATGGAAGCCGGCAAGACCAAGCTGGCCAGCCACGGCCTGGACCTGGTCGATGCCATGGTGGTGGCCGCCGACGACTCCTGCTCCGACGAGAAGGTCGCCGAGTACGAGCGCAGCGCCTGCCCGACCTGCGGCTCCTGCTCCGGCATGTTCACCGCCAACTCGATGAACTGCCTGACCGAGGCGCTCGGCCTGTCGCTGCCGGGCAACGGCTCGACCCTGGCCACCCACGCCGACCGCGAGCAACTGTTCCTACGCGCCGGGCGCCTGGCCGTGGAACTCTGCCAGCGCTATTACGGCGAAGGCGACGACAGCGTGCTGCCGCGCAACATCGCCAACTTCAAGGCCTTCGAGAACGCCATGACCCTGGACATCGCCATGGGCGGCTCGACCAATACCATCCTGCACCTGCTGGCCGCCGCCCAGGAGGCCGAGGTGCCGTTCGACCTGCGCGACATCGACCGCCTGTCGCGCAAGGTGCCGCAACTGTGCAAGGTGGCGCCGAACATCCAGAAGTACCACATGGAAGACGTGCATCGCGCCGGCGGCATCTTCTCCATCCTCGGCGAACTGGCCCGCGGTGGCCTGCTGCACACCGACGTCCCCACCGTGCACAGCCCGAGCATGGCCGACGCCATCGCCCAGTGGGACATCACCCAGACCCGCGACGAAGCCGTGCACACCTTCTTCAAGGCCGGTCCGGCGGGCATCCCGACCCAGACCGCGTTCAGCCAGAACACCCGCTGGCCGAGCCTGGACGACGACCGCGCCGAGGGCTGCATCCGCAGCGTCGAGCATGCCTATTCCAAGGAAGGCGGGCTGGCCGTGCTCTACGGCAACATCGCTCTCGACGGCTGCGTGGTGAAGACCGCCGGGGTCGACGAGTCGATCCACGTGTTCGAAGGCAGCGCGAAGATCTTCGAAAGCCAGGACGCCGCGGTGAAAGGCATCCTCGGCGACGAGGTGAAGGCCGGCGACATCGTGATCATCCGCTACGAAGGACCGAAGGGCGGGCCGGGCATGCAGGAAATGCTCTATCCGACCAGCTACCTGAAGTCCAAGGGCCTGGGCAAGCAGTGCGCCCTGCTCACCGACGGACGCTTCTCCGGCGGCACCTCGGGCCTGTCCATCGGCCACGCCTCCCCGGAAGCCGCCGCCGGCGGCGCCATCGGCCTGGTGCAGGACGGCGACAAGGTGCTGATCGACATTCCCAATCGCTCGATCAACCTGCTGGTCAGCGACGAAGAACTCGCCGCACGCCGCGCCGAACAGGACAAGAAGGGCTGGAAGCCGGCCGCGCCGCGTGCCCGCCGCGTCAGCACCGCGCTCAAGGCCTACGCCCTGCTCGCCACCAGCGCCGACAAGGGCGCGGTACGCAACAAGGCGCTGCTGGACGGCTGA |
Protein Properties |
Protein Residues: |
612 |
Protein Molecular Weight: |
65.2 kDa |
Protein Theoretical pI: |
5.98 |
Hydropathicity (GRAVY score): |
-0.11 |
Charge at pH 7 (predicted): |
-9.52 |
Protein Sequence: |
>PA0353
MPDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLASHGLDLVDAMVVAADDSCSDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGRLAVELCQRYYGEGDDSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPNIQKYHMEDVHRAGGIFSILGELARGGLLHTDVPTVHSPSMADAIAQWDITQTRDEAVHTFFKAGPAGIPTQTAFSQNTRWPSLDDDRAEGCIRSVEHAYSKEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDAAVKGILGDEVKAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLVSDEELAARRAEQDKKGWKPAAPRARRVSTALKAYALLATSADKGAVRNKALLDG |
References |
External Links: |
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General Reference: |
PaperBLAST - Find papers about PA0353 and its homologs
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