Reaction Details
Reaction: Thumb
L-tryptophan + oxygen → N-formylkynurenine
Enzymes: Not Available
External Links:
ResourceLink
PseudoCyc Reaction ID:RXN-8665
References:
  • Dang Y, Dale WE, Brown OR (2000). "Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway." Free Radic Biol Med 28(4);615-24. PMID: 10719243
  • Hirata F, Ohnishi T, Hayaishi O (1977). "Indoleamine 2,3-dioxygenase. Characterization and properties of enzyme. O2- complex." J Biol Chem 252(13);4637-42. PMID: 194886
  • Leeds JM, Brown PJ, McGeehan GM, Brown FK, Wiseman JS (1993). "Isotope effects and alternative substrate reactivities for tryptophan 2,3-dioxygenase." J Biol Chem 268(24);17781-6. PMID: 8349662
  • Littlejohn TK, Takikawa O, Truscott RJ, Walker MJ (2003). "Asp274 and his346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase." J Biol Chem 278(32);29525-31. PMID: 12766158
  • Ren S, Liu H, Licad E, Correia MA (1996). "Expression of rat liver tryptophan 2,3-dioxygenase in Escherichia coli: structural and functional characterization of the purified enzyme." Arch Biochem Biophys 333(1);96-102. PMID: 8806758
  • Sono M (1990). "Spectroscopic and equilibrium studies of ligand and organic substrate binding to indolamine 2,3-dioxygenase." Biochemistry 29(6);1451-60. PMID: 2334706
  • Takikawa O, Yoshida R, Kido R, Hayaishi O (1986). "Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase." J Biol Chem 261(8);3648-53. PMID: 2419335
  • Thomas SR, Stocker R (1999). "Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway." Redox Rep 4(5);199-220. PMID: 10731095
  • Uchida K, Shimizu T, Makino R, Sakaguchi K, Iizuka T, Ishimura Y, Nozawa T, Hatano M (1983). "Magnetic and natural circular dichroism of L-tryptophan 2,3-dioxygenases and indoleamine 2,3-dioxygenase. I. Spectra of ferric and ferrous high spin forms." J Biol Chem 258(4);2519-25. PMID: 6600455
  • Yamamoto S, Hayaishi O (1967). "Tryptophan pyrrolase of rabbit intestine. D- and L-tryptophan-cleaving enzyme or enzymes." J Biol Chem 242(22);5260-6. PMID: 6065097
  • Yasui H, Takai K, Yoshida R, Hayaishi O (1986). "Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients." Proc Natl Acad Sci U S A 83(17);6622-6. PMID: 2428037