Reaction Details
Reaction: Thumb
N,N-dimethylaniline + NADPH + oxygen + H+N,N-dimethylaniline-N-oxide + N,N-dimethylaniline-N-oxide + NADP+ + H2O
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:1.14.13.8-RXN
References:
  • Cashman JR, Zhang J (2006). "Human flavin-containing monooxygenases." Annu Rev Pharmacol Toxicol 46;65-100. PMID: 16402899
  • Chiba K, Kubota E, Miyakawa T, Kato Y, Ishizaki T (1988). "Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice." J Pharmacol Exp Ther 246(3);1108-15. PMID: 3262153
  • Chiba K, Kobayashi K, Itoh K, Itoh S, Chiba T, Ishizaki T, Kamataki T (1995). "N-oxygenation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by the rat liver flavin-containing monooxygenase expressed in yeast cells." Eur J Pharmacol 293(1);97-100. PMID: 7672012
  • Jones KC, Ballou DP (1986). "Reactions of the 4a-hydroperoxide of liver microsomal flavin-containing monooxygenase with nucleophilic and electrophilic substrates." J Biol Chem 261(6);2553-9. PMID: 3949735
  • Ziegler DM, Pettit FH (1966). "Microsomal oxidases. I. The isolation and dialkylarylamine oxygenase activity of pork liver microsomes." Biochemistry 5(9);2932-8. PMID: 4381353