Reaction Details
Reaction: Thumb
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-α-D-glucosamine + H2O → UDP-3-O-(3-hydroxymyristoyl)-α-D-glucosamine + acetate
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:UDPACYLGLCNACDEACETYL-RXN
References:
  • Hernick M, Gennadios HA, Whittington DA, Rusche KM, Christianson DW, Fierke CA (2005). "UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism." J Biol Chem 280(17);16969-78. PMID: 15705580
  • Hyland SA, Eveland SS, Anderson MS (1997). "Cloning, expression, and purification of UDP-3-O-acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: a metalloamidase of the lipid A biosynthesis pathway." J Bacteriol 179(6);2029-37. PMID: 9068651
  • Jackman JE, Raetz CR, Fierke CA (1999). "UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme." Biochemistry 1999;38(6);1902-11. PMID: 10026271
  • Mochalkin I, Knafels JD, Lightle S (2008). "Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor." Protein Sci 17(3);450-7. PMID: 18287278
  • Wang W, Maniar M, Jain R, Jacobs J, Trias J, Yuan Z (2001). "A fluorescence-based homogeneous assay for measuring activity of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase." Anal Biochem 290(2);338-46. PMID: 11237337
  • Whittington DA, Rusche KM, Shin H, Fierke CA, Christianson DW (2003). "Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis." Proc Natl Acad Sci U S A 100(14);8146-50. PMID: 12819349