Reaction Details
Reaction: Thumb
a peptide with a leader sequence + H2O → a peptide + a leader sequence
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:3.4.21.89-RXN
References:
  • Black MT (1993). "Evidence that the catalytic activity of prokaryote leader peptidase depends upon the operation of a serine-lysine catalytic dyad." J Bacteriol 175(16);4957-61. PMID: 8394311
  • Chaal BK, Mould RM, Barbrook AC, Gray JC, Howe CJ (1998). "Characterization of a cDNA encoding the thylakoidal processing peptidase from Arabidopsis thaliana. Implications for the origin and catalytic mechanism of the enzyme." J Biol Chem 273(2);689-92. PMID: 9422718
  • Inoue K, Baldwin AJ, Shipman RL, Matsui K, Theg SM, Ohme-Takagi M (2005). "Complete maturation of the plastid protein translocation channel requires a type I signal peptidase." J Cell Biol 171(3);425-30. PMID: 16275749
  • Lively MO, Newsome AL, Nusier M (1994). "Eukaryote microsomal signal peptidases." Methods Enzymol 244;301-14. PMID: 7845216
  • Nunnari J, Fox TD, Walter P (1993). "A mitochondrial protease with two catalytic subunits of nonoverlapping specificities." Science 262(5142);1997-2004. PMID: 8266095
  • Tschantz WR, Sung M, Delgado-Partin VM, Dalbey RE (1993). "A serine and a lysine residue implicated in the catalytic mechanism of the Escherichia coli leader peptidase." J Biol Chem 268(36);27349-54. PMID: 8262975
  • Tschantz WR, Dalbey RE (1994). "Bacterial leader peptidase 1." Methods Enzymol 244;285-301. PMID: 7845215