Reaction Details
Reaction: Thumb
di-trans,poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = di-trans,poly-cis-undecaprenyl diphosphate + diphosphate
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:DECAPCISTRANSFER-RXN
References:
  • Fujihashi M, Zhang YW, Higuchi Y, Li XY, Koyama T, Miki K (2001). "Crystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthase." Proc Natl Acad Sci U S A 98(8);4337-42. PMID: 11287651
  • Fujikura K, Zhang YW, Fujihashi M, Miki K, Koyama T (2003). "Mutational analysis of allylic substrate binding site of Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase." Biochemistry 42(14);4035-41. PMID: 12680756
  • Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH (2005). "Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis." J Biol Chem 280(21);20762-74. PMID: 15788389
  • Kharel Y, Zhang YW, Fujihashi M, Miki K, Koyama T, Khare Y (2003). "Significance of highly conserved aromatic residues in Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase." J Biochem 134(6);819-26. PMID: 14769870
  • Ko TP, Chen YK, Robinson H, Tsai PC, Gao YG, Chen AP, Wang AH, Liang PH (2001). "Mechanism of product chain length determination and the role of a flexible loop in Escherichia coli undecaprenyl-pyrophosphate synthase catalysis." J Biol Chem 276(50);47474-82. PMID: 11581264
  • Muth JD, Allen CM (1984). "Undecaprenyl pyrophosphate synthetase from Lactobacillus plantarum: a dimeric protein." Arch Biochem Biophys 230(1);49-60. PMID: 6712246
  • Pan JJ, Chiou ST, Liang PH (2000). "Product distribution and pre-steady-state kinetic analysis of Escherichia coli undecaprenyl pyrophosphate synthase reaction." Biochemistry 39(35);10936-42. PMID: 10978182
  • Takahashi I, Ogura K (1982). "Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase." J Biochem 92(5);1527-37. PMID: 6818223