Reaction Details
Reaction: Thumb
phosphonoacetaldehyde + H2O → acetaldehyde + phosphate + H+
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:PHOSPHONOACETALDEHYDE-HYDROLASE-RXN
References:
  • Baker AS, Ciocci MJ, Metcalf WW, Kim J, Babbitt PC, Wanner BL, Martin BM, Dunaway-Mariano D (1998). "Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis." Biochemistry 37(26);9305-15. PMID: 9649311
  • La Nauze JM, Rosenberg H (1968). "The identification of 2-phosphonoacetaldehyde as an intermediate in the degradation of 2-aminoethylphosphonate by Bacillus cereus." Biochim Biophys Acta 165(3);438-47. PMID: 4982500
  • La Nauze JM, Rosenberg H, Shaw DC (1970). "The enzymic cleavage of the carbon-phosphorus bond: purification and properties of phosphonatase." Biochim Biophys Acta 212(2);332-50. PMID: 4989158
  • La Nauze JM, Coggins JR, Dixon HB (1977). "Aldolase-like imine formation in the mechanism of action of phosphonoacetaldehyde hydrolase." Biochem J 165(2);409-11. PMID: 200222
  • Olsen DB, Hepburn TW, Moos M, Mariano PS, Dunaway-Mariano D (1988). "Investigation of the Bacillus cereus phosphonoacetaldehyde hydrolase. Evidence for a Schiff base mechanism and sequence analysis of an active-site peptide containing the catalytic lysine residue." Biochemistry 27(6);2229-34. PMID: 3132206