Reaction Details
Reaction: Thumb
pyridoxamine 5'-phosphate + oxygen + H2O → ammonium + hydrogen peroxide + pyridoxal 5'-phosphate
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:PMPOXI-RXN
References:
  • Choi JD, Bowers-Komro M, Davis MD, Edmondson DE, McCormick DB (1983). "Kinetic properties of pyridoxamine (pyridoxine)-5'-phosphate oxidase from rabbit liver." J Biol Chem 258(2);840-5. PMID: 6822512
  • Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS (1999). "Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein." FEBS Lett 1999;449(1);45-8. PMID: 10225425
  • Musayev FN, Di Salvo ML, Ko TP, Schirch V, Safo MK (2003). "Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase." Protein Sci 12(7);1455-63. PMID: 12824491
  • Notheis C, Drewke C, Leistner E (1995). "Purification and characterization of the pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating) from Escherichia coli." Biochim Biophys Acta 1247(2);265-71. PMID: 7696318
  • Safo MK, Musayev FN, Schirch V (2005). "Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in a tetragonal crystal form: insights into the mechanistic pathway of the enzyme." Acta Crystallogr D Biol Crystallogr 61(Pt 5);599-604. PMID: 15858270
  • Wada H, Snell EE (1961). "The enzymatic oxidation of pyridoxine and pyridoxamine phosphates." J Biol Chem 236;2089-95. PMID: 13782387
  • Zhang Z, McCormick DB (1992). "Uptake and metabolism of N-(4'-pyridoxyl)amines by isolated rat liver cells." Arch Biochem Biophys 294(2);394-7. PMID: 1567194