Reaction 21609

Reaction Details
Reaction: Thumb
a tetrahydrofolate + NADP+ ← a 7,8-dihydrofolate + NADPH + H+
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:DIHYDROFOLATEREDUCT-RXN
References:
  • Bolin JT, Filman DJ, Matthews DA, Hamlin RC, Kraut J (1982). "Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate." J Biol Chem 257(22);13650-62. PMID: 6815178
  • Kaufman BT, Gardiner RC (1966). "Studies on dihydrofolic reductase. I. Purification and properties of dihydrofolic reductase from chicken liver." J Biol Chem 241(6);1319-28. PMID: 4379915
  • Young IG, Gibson F (1969). "Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli." Biochim Biophys Acta 177(3);401-11. PMID: 4306838