Reaction Details
Reaction: Thumb
(S)-dihydroorotate + fumarate → orotate + succinate
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:RXN-9929
References:
  • Bjornberg O, Rowland P, Larsen S, Jensen KF (1997). "Active site of dihydroorotate dehydrogenase A from Lactococcus lactis investigated by chemical modification and mutagenesis." Biochemistry 36(51);16197-205. PMID: 9405053
  • Cheleski J, Wiggers HJ, Citadini AP, da Costa Filho AJ, Nonato MC, Montanari CA (2010). "Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry." Anal Biochem 399(1);13-22. PMID: 19932077
  • Inaoka DK, Sakamoto K, Shimizu H, Shiba T, Kurisu G, Nara T, Aoki T, Kita K, Harada S (2008). "Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction." Biochemistry 47(41);10881-91. PMID: 18808149
  • Norager S, Arent S, Bjornberg O, Ottosen M, Lo Leggio L, Jensen KF, Larsen S (2003). "Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function." J Biol Chem 278(31);28812-22. PMID: 12732650
  • Rowland P, Bjornberg O, Nielsen FS, Jensen KF, Larsen S (1998). "The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function." Protein Sci 7(6);1269-79. PMID: 9655329
  • Zameitat E, Pierik AJ, Zocher K, Loffler M (2007). "Dihydroorotate dehydrogenase from Saccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues." FEMS Yeast Res 7(6);897-904. PMID: 17617217