Reaction Details
Reaction: Thumb
NAD+ + H2O → ADP-D-ribose + nicotinamide + H+
Enzymes: Not Available
External Links:
ResourceLink
PseudoCyc Reaction ID:NADNUCLEOSID-RXN
References:
  • Fryxell KB, O'Donoghue K, Graeff RM, Lee HC, Branton WD (1995). "Functional expression of soluble forms of human CD38 in Escherichia coli and Pichia pastoris." Protein Expr Purif 6(3);329-36. PMID: 7663169
  • Howard M, Grimaldi JC, Bazan JF, Lund FE, Santos-Argumedo L, Parkhouse RM, Walseth TF, Lee HC (1993). "Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38." Science 262(5136);1056-9. PMID: 8235624
  • Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q (2005). "Crystal structure of human CD38 extracellular domain." Structure 13(9);1331-9. PMID: 16154090
  • Takasawa S, Tohgo A, Noguchi N, Koguma T, Nata K, Sugimoto T, Yonekura H, Okamoto H (1993). "Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP." J Biol Chem 268(35);26052-4. PMID: 8253715
  • Tohgo A, Takasawa S, Noguchi N, Koguma T, Nata K, Sugimoto T, Furuya Y, Yonekura H, Okamoto H (1994). "Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38." J Biol Chem 269(46);28555-7. PMID: 7961800
  • Yamamoto-Katayama S, Ariyoshi M, Ishihara K, Hirano T, Jingami H, Morikawa K (2002). "Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities." J Mol Biol 316(3);711-23. PMID: 11866528