Reaction 21502

Reaction Details
Reaction: Thumb
4 porphobilinogen + H2O → 4 ammonium + preuroporphyrinogen
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:OHMETHYLBILANESYN-RXN
References:
  • Battersby AR (2000). "Tetrapyrroles: the pigments of life." Nat Prod Rep 17(6);507-26. PMID: 11152419
  • Battersby AR, Fookes CJ, Matcham GW, McDonald E (1980). "Biosynthesis of the pigments of life: formation of the macrocycle." Nature 285(5759);17-21. PMID: 6769048
  • Frydman RB, Feinstein G (1974). "Studies on porphobilinogen deaminase and uroporphyrinogen 3 cosynthase from human erythrocytes." Biochim Biophys Acta 350(2);358-73. PMID: 4847568
  • Levin EY, Coleman DL (1967). "The enzymatic conversion of porphobilinogen to uroporphyrinogen catalyzed by extracts of hematopoietic mouse spleen." J Biol Chem 242(18);4247-53. PMID: 6061709
  • Miller AD, Hart GJ, Packman LC, Battersby AR (1988). "Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound to the protein through the sulphur atom of cysteine-242." Biochem J 254(3);915-8. PMID: 3196304
  • Warren MJ, Jordan PM (1988). "Investigation into the nature of substrate binding to the dipyrromethane cofactor of Escherichia coli porphobilinogen deaminase." Biochemistry 1988;27(25);9020-30. PMID: 3069132