Reaction 21494

Reaction Details
Reaction: Thumb
orotidine 5'-phosphate + diphosphate ← 5-phospho-α-D-ribose 1-diphosphate + orotate
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:OROPRIBTRANS-RXN
References:
  • Jones ME, Kavipurapu PR, Traut TW (1978). "Orotate phosphoribosyltransferase: orotidylate decarboxylase (Ehrlich ascites cell)." Methods Enzymol 51;155-67. PMID: 692383
  • LIEBERMAN I, KORNBERG A, SIMMS ES (1955). "Enzymatic synthesis of pyrimidine nucleotides; orotidine-5'-phosphate and uridine-5'-phosphate." J Biol Chem 215(1);403-51. PMID: 14392174
  • McClard RW, Black MJ, Livingstone LR, Jones ME (1980). "Isolation and initial characterization of the single polypeptide that synthesizes uridine 5'-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'-monophosphate synthase." Biochemistry 19(20);4699-706. PMID: 6893554