Reaction Details
Reaction: Thumb
L-cysteine + O-succinyl-L-homoserine → succinate + L-cystathionine + H+
Enzymes: Not Available
External Links:
ResourceLink
PseudoCyc Reaction ID:O-SUCCHOMOSERLYASE-RXN
References:
  • Clausen T, Huber R, Prade L, Wahl MC, Messerschmidt A (1998). "Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution." EMBO J 17(23);6827-38. PMID: 9843488
  • Flavin M, Slaughter C (1967). "Enzymatic synthesis of homocysteine or methionine directly from O-succinyl-homoserine." Biochim Biophys Acta 132(2);400-5. PMID: 5340123
  • Kaplan MM, Flavin M (1966). "Cystathionine gamma-synthetase of Salmonella. Catalytic properties of a new enzyme in bacterial methionine biosynthesis." J Biol Chem 241(19);4463-71. PMID: 5922970
  • Ravanel S, Gakiere B, Job D, Douce R (1998). "Cystathionine gamma-synthase from Arabidopsis thaliana: purification and biochemical characterization of the recombinant enzyme overexpressed in Escherichia coli." Biochem J 1998;331 ( Pt 2);639-48. PMID: 9531508
  • Wiebers JL, Garner HR (1967). "Homocysteine and cysteine synthetases of Neurospora crassa. Purification, properties, and feedback control of activity." J Biol Chem 242(1);12-23. PMID: 6016326
  • Wiebers JL, Garner HR (1967). "Acyl derivatives of homoserine as substrates for homocysteine synthesis in Neurospora crassa, yeast, and Escherichia coli." J Biol Chem 242(23);5644-9. PMID: 12325384