Reaction Details
Reaction: Thumb
(S)-dihydroorotate[in] + an electron-transfer quinone[membrane] → orotate[in] + an electron-transfer quinol[membrane]
Enzymes: Not Available
External Links:
ResourceLink
PseudoCyc Reaction ID:DIHYDROOROTATE-DEHYDROGENASE-RXN
References:
  • Bader B, Knecht W, Fries M, Loffler M (1998). "Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase." Protein Expr Purif 13(3);414-22. PMID: 9693067
  • Bjornberg O, Gruner AC, Roepstorff P, Jensen KF (1999). "The activity of Escherichia coli dihydroorotate dehydrogenase is dependent on a conserved loop identified by sequence homology, mutagenesis, and limited proteolysis." Biochemistry 38(10);2899-908. PMID: 10074342
  • Fagan RL, Nelson MN, Pagano PM, Palfey BA (2006). "Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases." Biochemistry 45(50);14926-32. PMID: 17154530
  • Forman HJ, Kennedy J (1978). "Mammalian dihydroorotate dehydrogenase: physical and catalytic properties of the primary enzyme." Arch Biochem Biophys 191(1);23-31. PMID: 216313
  • Hines V, Keys LD, Johnston M (1986). "Purification and properties of the bovine liver mitochondrial dihydroorotate dehydrogenase." J Biol Chem 261(24);11386-92. PMID: 3733756