Reaction Details
Reaction: Thumb
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + an oxidized flavodoxin + H2O + H+ ← 2-C-methyl-D-erythritol-2,4-cyclodiphosphate + a reduced flavodoxin
Enzymes: Not Available
External Links:
ResourceLink
PseudoCyc Reaction ID:RXN-15878
References:
  • Hecht S, Eisenreich W, Adam P, Amslinger S, Kis K, Bacher A, Arigoni D, Rohdich F (2001). "Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein." Proc Natl Acad Sci U S A 98(26);14837-42. PMID: 11752431
  • Puan KJ, Wang H, Dairi T, Kuzuyama T, Morita CT (2005). "fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis." FEBS Lett 579(17);3802-6. PMID: 15978585
  • Seemann M, Bui BT, Wolff M, Tritsch D, Campos N, Boronat A, Marquet A, Rohmer M (2002). "Isoprenoid biosynthesis through the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) is a [4Fe-4S] protein." Angew Chem Int Ed Engl 41(22);4337-9. PMID: 12434382
  • Zepeck F, Grawert T, Kaiser J, Schramek N, Eisenreich W, Bacher A, Rohdich F (2005). "Biosynthesis of Isoprenoids. Purification and Properties of IspG Protein from Escherichia coli." J Org Chem 70(23);9168-74. PMID: 16268586