P. aeruginosa Metabolome Database Reaction 21431

Reaction Details

Reaction:

FMNH₂ + oxygen → 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate

Enzymes:

Not Available

External Links:

Resource	Link
PseudoCyc Reaction ID:	RXN-8771

References:

Ealick SE, Begley TP (2007). "Biochemistry: molecular cannibalism." Nature 446(7134);387-8. PMID: 17377573
Gray MJ, Escalante-Semerena JC (2007). "Single-enzyme conversion of FMNH2 to 5,6-dimethylbenzimidazole, the lower ligand of B12." Proc Natl Acad Sci U S A 104(8);2921-6. PMID: 17301238
Taga ME, Larsen NA, Howard-Jones AR, Walsh CT, Walker GC (2007). "BluB cannibalizes flavin to form the lower ligand of vitamin B12." Nature 446(7134);449-53. PMID: 17377583
Wang XL, Quan JM (2011). "Intermediate-assisted multifunctional catalysis in the conversion of flavin to 5,6-dimethylbenzimidazole by BluB: a density functional theory study." J Am Chem Soc 133(11);4079-91. PMID: 21344938