Reaction Details
Reaction: Thumb
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate → 2-succinylbenzoate + H2O
Enzymes: Not Available
External Links:
ResourceLink
PseudoCyc Reaction ID:O-SUCCINYLBENZOATE-COA-SYN-RXN
References:
  • Klenchin VA, Taylor Ringia EA, Gerlt JA, Rayment I (2003). "Evolution of enzymatic activity in the enolase superfamily: structural and mutagenic studies of the mechanism of the reaction catalyzed by o-succinylbenzoate synthase from Escherichia coli." Biochemistry 42(49);14427-33. PMID: 14661953
  • Palmer DR, Garrett JB, Sharma V, Meganathan R, Babbitt PC, Gerlt JA (1999). "Unexpected divergence of enzyme function and sequence: "N-acylamino acid racemase" is o-succinylbenzoate synthase." Biochemistry 38(14);4252-8. PMID: 10194342
  • Sharma V, Meganathan R, Hudspeth ME (1993). "Menaquinone (vitamin K2) biosynthesis: cloning, nucleotide sequence, and expression of the menC gene from Escherichia coli." J Bacteriol 1993;175(15);4917-21. PMID: 8335646
  • Taylor Ringia EA, Garrett JB, Thoden JB, Holden HM, Rayment I, Gerlt JA (2004). "Evolution of enzymatic activity in the enolase superfamily: functional studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis." Biochemistry 43(1);224-9. PMID: 14705949
  • Thompson TB, Garrett JB, Taylor EA, Meganathan R, Gerlt JA, Rayment I (2000). "Evolution of enzymatic activity in the enolase superfamily: structure of o-succinylbenzoate synthase from Escherichia coli in complex with Mg2+ and o-succinylbenzoate." Biochemistry 39(35);10662-76. PMID: 10978150