Reaction Details
Reaction: Thumb
isochorismate + 2-oxoglutarate + H+ → 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate + CO2
Enzymes: Not Available
External Links:
ResourceLink
PseudoCyc Reaction ID:2.5.1.64-RXN
References:
  • Jiang M, Cao Y, Guo ZF, Chen M, Chen X, Guo Z (2007). "Menaquinone biosynthesis in Escherichia coli: identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate as a novel intermediate and re-evaluation of MenD activity." Biochemistry 46(38);10979-89. PMID: 17760421