Reaction 21393

Reaction Details
Reaction: Thumb
4-hydroxyphenylacetate + FADH2 + oxygen → 3,4-dihydroxyphenylacetate + FAD + H+ + H2O
Enzymes: Not Available
External Links:
ResourceLink
PseudoCyc Reaction ID:RXN-8505
References:
  • Adachi K, Takeda Y, Senoh S, Kita H (1964). "Metabolism of p-hydroxyphenylacetic acid in Pseudomonas ovalis." Biochim Biophys Acta 93;483-93. PMID: 14263147
  • Galan B, Diaz E, Prieto MA, Garcia JL (2000). "Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: a prototype of a new Flavin:NAD(P)H reductase subfamily." J Bacteriol 182(3);627-36. PMID: 10633095
  • Louie TM, Xie XS, Xun L (2003). "Coordinated production and utilization of FADH2 by NAD(P)H-flavin oxidoreductase and 4-hydroxyphenylacetate 3-monooxygenase." Biochemistry 42(24);7509-17. PMID: 12809507
  • Prieto MA, Perez-Aranda A, Garcia JL (1993). "Characterization of an Escherichia coli aromatic hydroxylase with a broad substrate range." J Bacteriol 175(7);2162-7. PMID: 8458860
  • Prieto MA, Garcia JL (1994). "Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme." J Biol Chem 269(36);22823-9. PMID: 8077235
  • Xun L, Sandvik ER (2000). "Characterization of 4-hydroxyphenylacetate 3-hydroxylase (HpaB) of Escherichia coli as a reduced flavin adenine dinucleotide-utilizing monooxygenase." Appl Environ Microbiol 66(2);481-6. PMID: 10653707