Reaction 21389

Reaction Details
Reaction: Thumb
an N5-methyl-tetrahydrofolate + NAD+ ← a 5,10-methylene-tetrahydrofolate + NADH + H+
Enzymes: Not Available
External Links:
ResourceLink
PseudoCyc Reaction ID:1.5.1.20-RXN
References:
  • Daubner SC, Matthews RG (1982). "Purification and properties of methylenetetrahydrofolate reductase from pig liver." J Biol Chem 257(1);140-5. PMID: 6975779
  • Guenther BD, Sheppard CA, Tran P, Rozen R, Matthews RG, Ludwig ML (1999). "The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia." Nat Struct Biol 6(4);359-65. PMID: 10201405
  • Kutzbach C, Stokstad EL (1971). "Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine." Biochim Biophys Acta 250(3);459-77. PMID: 4399897
  • Sheppard CA, Trimmer EE, Matthews RG (1999). "Purification and properties of NADH-dependent 5, 10-methylenetetrahydrofolate reductase (MetF) from Escherichia coli." J Bacteriol 181(3);718-25. PMID: 9922232