Reaction 21246

Reaction Details
Reaction: Thumb
(2R,3S)-3-isopropylmalate + NAD+ = 4-methyl-2-oxopentanoate + CO2 + NADH
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:RXN-13158
References:
  • Burns RO, Umbarger HE, Gross SR (1963). "The biosynthesis of leucine. Iii. The conversion of alpha-hydroxy-beta-carboxyisocaproate to alpha-ketoisocaproate." Biochemistry 2;1053-8. PMID: 14087358
  • Calvo JM, Stevens CM, KalyanpurMG, Umbarger HE (1964). "The absolute configuration of alpha-hydroxy-beta-carboxyisocaproic acid (3-isopropylmalic acid), an intermediate in leucine biosynthesis." Biochemistry 3;2024-7. PMID: 14269331
  • Nemeth A, Svingor A, Pocsik M, Dobo J, Magyar C, Szilagyi A, Gal P, Zavodszky P (2000). "Mirror image mutations reveal the significance of an intersubunit ion cluster in the stability of 3-isopropylmalate dehydrogenase." FEBS Lett 468(1);48-52. PMID: 10683439
  • Parsons SJ, Burns RO (1969). "Purification and properties of beta-isopropylmalate dehydrogenase." J Biol Chem 1969;244(3);996-1003. PMID: 4889950