Reaction Details
Reaction: Thumb
7,8-dihydroneopterin → glycolaldehyde + 6-hydroxymethyl-7,8-dihydropterin
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:H2NEOPTERINALDOL-RXN
References:
  • Blaszczyk J, Lu Z, Li Y, Yan H, Ji X (2014). "Crystallographic and molecular dynamics simulation analysis of Escherichia coli dihydroneopterin aldolase." Cell Biosci 4(1);52. PMID: 25264482
  • Czekster CM, Blanchard JS (2012). "One substrate, five products: reactions catalyzed by the dihydroneopterin aldolase from Mycobacterium tuberculosis." J Am Chem Soc 134(48);19758-71. PMID: 23150985
  • Goyer A, Illarionova V, Roje S, Fischer M, Bacher A, Hanson AD (2004). "Folate biosynthesis in higher plants. cDNA cloning, heterologous expression, and characterization of dihydroneopterin aldolases." Plant Physiol 135(1);103-11. PMID: 15107504
  • Guldener U, Koehler GJ, Haussmann C, Bacher A, Kricke J, Becher D, Hegemann JH (2004). "Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth." Mol Biol Cell 15(8);3811-28. PMID: 15169867
  • Haussmann C, Rohdich F, Schmidt E, Bacher A, Richter G (1998). "Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase." J Biol Chem 273(28);17418-24. PMID: 9651328
  • Mathis JB, Brown GM (1970). "The biosynthesis of folic acid. XI. Purification and properties of dihydroneopterin aldolase." J Biol Chem 1970;245(11);3015-25. PMID: 4912541
  • Wang Y, Xu H, Grochowski LL, White RH (2014). "Biochemical characterization of a dihydroneopterin aldolase used for methanopterin biosynthesis in methanogens." J Bacteriol 196(17);3191-8. PMID: 24982305