Reaction Details
Reaction: Thumb
7,8-dihydroneopterin 3'-triphosphate + H2O → 7,8-dihydroneopterin 3'-phosphate + diphosphate + H+
Enzymes: Not Available
External Links:
ResourceLink
PseudoCyc Reaction ID:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN
References:
  • Gabelli SB, Bianchet MA, Xu W, Dunn CA, Niu ZD, Amzel LM, Bessman MJ (2007). "Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis." Structure 15(8);1014-22. PMID: 17698004
  • Klaus SM, Wegkamp A, Sybesma W, Hugenholtz J, Gregory JF, Hanson AD (2005). "A nudix enzyme removes pyrophosphate from dihydroneopterin triphosphate in the folate synthesis pathway of bacteria and plants." J Biol Chem 280(7);5274-80. PMID: 15611104
  • O'Handley SF, Frick DN, Bullions LC, Mildvan AS, Bessman MJ (1996). "Escherichia coli orf17 codes for a nucleoside triphosphate pyrophosphohydrolase member of the MutT family of proteins. Cloning, purification, and characterization of the enzyme." J Biol Chem 1996;271(40);24649-54. PMID: 8798731
  • Suzuki Y, Brown GM (1974). "The biosynthesis of folic acid. XII. Purification and properties of dihydroneopterin triphosphate pyrophosphohydrolase." J Biol Chem 1974;249(8);2405-10. PMID: 4362677