Reaction Details
Reaction: Thumb
L-histidine → ammonium + urocanate
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:HISTIDINE-AMMONIA-LYASE-RXN
References:
  • Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore BS, Noel JP (2006). "Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases." Chem Biol 13(12);1327-38. PMID: 17185228
  • Mehler, A.H., Tabor, H. (1953). "Deamination of histidine to form urocanic acid in liver." J Biol Chem 201(2);775-84. PMID: 13061415
  • Poppe L, Retey J (2005). "Friedel-Crafts-type mechanism for the enzymatic elimination of ammonia from histidine and phenylalanine." Angew Chem Int Ed Engl 44(24);3668-88. PMID: 15906398
  • Schwede TF, Retey J, Schulz GE (1999). "Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile." Biochemistry 38(17);5355-61. PMID: 10220322
  • Watts KT, Mijts BN, Lee PC, Manning AJ, Schmidt-Dannert C (2006). "Discovery of a substrate selectivity switch in tyrosine ammonia-lyase, a member of the aromatic amino acid lyase family." Chem Biol 13(12);1317-26. PMID: 17185227