Reaction Details
Reaction: Thumb
L-homocysteine + an N5-methyl-tetrahydrofolate → L-methionine + a tetrahydrofolate
Enzymes: Not Available
External Links:
ResourceLink
PseudoCyc Reaction ID:HOMOCYSMETB12-RXN
References:
  • Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML (2002). "Domain alternation switches B(12)-dependent methionine synthase to the activation conformation." Nat Struct Biol 9(1);53-6. PMID: 11731805
  • Burton EG, Sakami W (1969). "The formation of methionine from the monoglutamate form of methyltetrahydrofolate by higher plants." Biochem Biophys Res Commun 36(2);228-34. PMID: 5799642
  • Foster MA, Dilworth MJ, Woods DD (1964). "Cobalamin and the synthesis of methionine by Escherichia coli." Nature 201;39-42. PMID: 14085561
  • Guest JR, Friedman S, Foster MA, Tejerina G, Woods DD (1964). "Transfer of the methyl group from N5-methyltetrahydrofolates to homocysteine in Escherichia coli." Biochem J 92(3);497-504. PMID: 5319972
  • Hall DA, Jordan-Starck TC, Loo RO, Ludwig ML, Matthews RG (2000). "Interaction of flavodoxin with cobalamin-dependent methionine synthase." Biochemistry 39(35);10711-9. PMID: 10978155
  • Jarrett JT, Huang S, Matthews RG (1998). "Methionine synthase exists in two distinct conformations that differ in reactivity toward methyltetrahydrofolate, adenosylmethionine, and flavodoxin." Biochemistry 37(16);5372-82. PMID: 9548919
  • Loughlin RE, Elford HL, Buchanan JM (1964). "Enzymatic synthesis of the methyl group of methionine. VII. Isolation of a cobalamin-containing transmethylase (5-methyltetrahydro-folate-homocysteine) from mammalian liver." J Biol Chem 239;2888-95. PMID: 14216440
  • Taylor RT (1971). "Escherichia coli B N 5 -methyltetrahydrofolate-homocysteine cobalamin methyltransferase: gel-filtration behavior of apoenzyme and holoenzymes." Biochim Biophys Acta 242(2);355-64. PMID: 4946148