4-hydroxybenzoate octaprenyltransferase (PA5358)

Identification
Name: 4-hydroxybenzoate octaprenyltransferase
Synonyms:
  • 4-HB polyprenyltransferase
Gene Name: ubiA
Enzyme Class:
Biological Properties
General Function: Involved in prenyltransferase activity
Specific Function: Synthesis of 3-octaprenyl-4-hydroxybenzoate
Cellular Location: Cell inner membrane; Multi-pass membrane protein
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb
4-Hydroxybenzoic acid + Octaprenyl diphosphate → 3-Octaprenyl-4-hydroxybenzoate + Pyrophosphate
ReactionCard
all-trans-Polyprenyl diphosphate+Thumb+Thumb ↔ 4-Hydroxy-3-polyprenylbenzoate+Thumb+Thumb
all-trans-Polyprenyl diphosphate + 4-Hydroxybenzoic acid + Geranyl-PP ↔ 4-Hydroxy-3-polyprenylbenzoate + Pyrophosphate + 4-Hydroxy-3-polyprenylbenzoate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Octaprenyl diphosphate + 4-Hydroxybenzoic acid ↔ 3-Octaprenyl-4-hydroxybenzoate + Pyrophosphate
ReactionCard
SMPDB Reactions:
Thumb+Octaprenyl diphosphate+Thumb → Pyrophosphate+Thumb
4-Hydroxybenzoic acid + Octaprenyl diphosphate + Octaprenyl diphosphate → Pyrophosphate + 3-Octaprenyl-4-hydroxybenzoate
ReactionCard
PseudoCyc/BioCyc Reactions:
all-trans-octaprenyl diphosphate+Thumb → Thumb+Thumb
all-trans-octaprenyl diphosphate + 4-Hydroxybenzoic acid → Pyrophosphate + 3-Octaprenyl-4-hydroxybenzoate
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb
4-Hydroxybenzoic acid + Octaprenyl diphosphate → 3-Octaprenyl-4-hydroxybenzoate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0015783-Octaprenyl-4-hydroxybenzoateMetaboCard
PAMDB0041834-Hydroxy-3-polyprenylbenzoateMetaboCard
PAMDB0001434-Hydroxybenzoic acidMetaboCard
Farnesylfarnesylgeranyl-PPMetaboCard
PAMDB000324Geranyl-PPMetaboCard
PAMDB000251Octaprenyl diphosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane part
Function
catalytic activity
prenyltransferase activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
Process
biosynthetic process
metabolic process
Gene Properties
Locus tag: PA5358
Strand: +
Entrez Gene ID: 880317
Accession: NP_254045.1
GI: 15600551
Sequence start: 6025305
Sequence End: 6026195
Sequence Length: 890
Gene Sequence: 
>PA5358
ATGTTCGTCACCCTGATCAAGCCGCTGGCCCGCCTGCACCCCCGCGCCTGGGACTTCGTCCAACTGGTGCGGCTGGACCGGCCGATCGGCATCTACCTGCTGCTCTGGCCGACCCTCTGGTCGCTGTGGATCGCCGCGGACGGCGTGCCGGAACTGAAGAACCTGCTGATCTTCGTCCTCGGCGTCATCCTGATGCGCGCCGCCGGCTGCGTGATCAACGATTTCGCCGACCGCAATTTCGACGGCCATGTCGCACGCACCAAGGCGCGCCCGCTGGCCACCGGCAAGATCAGCGTGCGCGAGGCCTGGATCACCTTCGCCGTCCTGGTCGCGCTGAGCTTCGGCCTGGTCCTGCTGACCAATGCAACGACCGTCTGGCTGTCGTTCGGCGCGGTAGCCGTGGCCTCGCTCTACCCCTTCATGAAGCGCTACACCTACTATCCGCAGGTGGTGCTGGGCGCCGCCTATTCCTGGGGCATCCTGATGGCCTTCACCGCCGAGCGCGGCGAATTGCCGGCCAGCGCCTGGCTGCTGTTCCTGGCCAACGTGCTGTGGACGGTCGCCTATGACTCCTACTACGCGATGACCGACCGCGAGGACGACCTGAAGATCGGCATCAAGTCCACCGCAATCCTCTTCGGCGATGCCGACCGCCTGATCATCGGCAGCCTGCAGGGCCTGACCCTGCTCCTGCTAGTGCTGGCCGGCAACCGCTTCGAACTGGGCCTGTGCTTCTACCTCGGCCTGGCGGTGGCGGCGGCCTGCTTCGTCTGGGAAGCCTGGTCGACCCGCGACCGCGACCCGCAGGCCTGCTTCCGCGCCTTCCTGCACAACCACTGGGCTGGCCTGGCGATCTTCCTCGGCACGGTCGCCGACTACGCGCTGCGTTGA
Protein Properties
Protein Residues: 296
Protein Molecular Weight: 33 kDa
Protein Theoretical pI: 8.58
Hydropathicity (GRAVY score): 0.632
Charge at pH 7 (predicted): 3.83
Protein Sequence: 
>PA5358
MFVTLIKPLARLHPRAWDFVQLVRLDRPIGIYLLLWPTLWSLWIAADGVPELKNLLIFVLGVILMRAAGCVINDFADRNFDGHVARTKARPLATGKISVREAWITFAVLVALSFGLVLLTNATTVWLSFGAVAVASLYPFMKRYTYYPQVVLGAAYSWGILMAFTAERGELPASAWLLFLANVLWTVAYDSYYAMTDREDDLKIGIKSTAILFGDADRLIIGSLQGLTLLLLVLAGNRFELGLCFYLGLAVAAACFVWEAWSTRDRDPQACFRAFLHNHWAGLAIFLGTVADYALR
References
External Links:
Resource Link
Genome ID: PA5358
Entrez Gene ID: 880317
NCBI Protein ID: 15600551
General Reference: PaperBLAST - Find papers about PA5358 and its homologs