Peptide methionine sulfoxide reductase msrA (PA5018)

Identification
Name: Peptide methionine sulfoxide reductase msrA
Synonyms:
  • Protein-methionine-S-oxide reductase
  • Peptide-methionine (S)-S-oxide reductase
  • Peptide Met(O) reductase
Gene Name: msrA
Enzyme Class:
Biological Properties
General Function: Involved in oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
Specific Function: Could have an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Cellular Location: Not Available
KEGG Pathways: Not Available
KEGG Reactions:
Peptide-L-methionine+Thioredoxin disulfide+Thumb+Thumb ↔ Peptide-L-methionine (S)-S-oxide+Thumb+Thumb
Peptide-L-methionine + Thioredoxin disulfide + Water + L-Methionine ↔ Peptide-L-methionine (S)-S-oxide + Thioredoxin + L-methionine (S)-S-oxide
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Peptide-L-methionine+thioredoxin disulfide+Thumb → peptide-L-methionine (S)-S-oxide+thioredoxin
Peptide-L-methionine + thioredoxin disulfide + Water → peptide-L-methionine (S)-S-oxide + thioredoxin
ReactionCard
Thumb+thioredoxin disulfide+Thumb → Thumb+thioredoxin
L-Methionine + thioredoxin disulfide + Water → L-methionine (S)-S-oxide + thioredoxin
ReactionCard
Peptide-L-methionine+Thioredoxin disulfide+Thumb+Thumb ↔ Peptide-L-methionine (S)-S-oxide+Thumb+Thumb
Peptide-L-methionine + Thioredoxin disulfide + Water + L-Methionine ↔ Peptide-L-methionine (S)-S-oxide + Thioredoxin + L-methionine (S)-S-oxide
ReactionCard
Thumb
a protein-L-methionine + an oxidized thioredoxin + a [protein]-L-methionine = a protein-L-methionine-(S)-S-oxide + a reduced thioredoxin + a protein-L-methionine-(S)-S-oxide
ReactionCard
Protein-L-methionine+PAMDB000142 → Protein-L-methionine-R-S-oxides
Protein-L-methionine + Water → Protein-L-methionine-R-S-oxides
ReactionCard
Protein-L-methionine+PAMDB000142 → Protein-L-Methionine-S-Oxides
Protein-L-methionine + Water → Protein-L-Methionine-S-Oxides
ReactionCard
Complex Reactions:
Thumb+Reduced Thioredoxin → Thumb+Thumb+Oxidized Thioredoxin
Methionine sulfoxide + Reduced Thioredoxin → Water + L-Methionine + Oxidized Thioredoxin
ReactionCard
Thumb+Reduced Thioredoxin → Thumb+Thumb+Oxidized Thioredoxin
Methionine sulfoxide + Reduced Thioredoxin → Water + L-Methionine + Oxidized Thioredoxin
ReactionCard
Peptide-L-methionine+thioredoxin disulfide+Thumb → peptide-L-methionine (S)-S-oxide+thioredoxin
Peptide-L-methionine + thioredoxin disulfide + Water → peptide-L-methionine (S)-S-oxide + thioredoxin
ReactionCard
Thumb+thioredoxin disulfide+Thumb → Thumb+thioredoxin
L-Methionine + thioredoxin disulfide + Water → L-methionine (S)-S-oxide + thioredoxin
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000175L-MethionineMetaboCard
PAMDB003507L-methionine (S)-S-oxideMetaboCard
PAMDB001133L-Methionine-(S)-S-oxideMetaboCard
PAMDB000428Methionine sulfoxideMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
Process
macromolecule metabolic process
metabolic process
oxidation reduction
protein metabolic process
Gene Properties
Locus tag: PA5018
Strand: +
Entrez Gene ID: 881240
Accession: NP_253705.1
GI: 15600211
Sequence start: 5643803
Sequence End: 5644450
Sequence Length: 647
Gene Sequence: 
>PA5018
ATGGTTCTGCGTTCTGAAATCCTCACCAAGAAAAGCGAGCTGCCCACGCCGGACCAGGCCCTGCCGGGTCGCGAAAGCGCCATGCCGGTGCCCGAAGCGCACTTCGTCAACGGCCGCCCGCTGACCGCGCCGTTCCCCGCCGGCCTGCAACAGGTGCTGTTCGGCATGGGCTGCTTCTGGGGCGCCGAGCGTCGCCTCTGGCAGCAACCGGGTGTCTGGGTGACCGCGGTGGGTTATGCCGGCGGCTACACGCCGAACCCGACCTACGACGAAGTCTGCTCCGGCCTGACCGGCCACAGCGAGGTCGTGCTGGTGGTCTACAACCCGCAGGAGACCAGCTTCGAACAGCTGCTCAAGGTATTCTGGGAAGCCCACGATCCGACCCAGGGCATGCGCCAGGGCGGCGACATCGGCACCCAGTACCGCTCGGTGATCTACACCTTCGACGCGGCCCAGAAAGCCGCGGCCATGGCCAGCCGGGAGAGCTTCCAGGCCGAACTGGCGAAAGCCGGCTACGACCGCATCACCACCGAGATCGCCGACGTCCCGCCCTTCTACTACGCCGAGGCCTACCACCAGCAGTACCTGGCGAAGAACCCCAACGGCTACTGCGGCCTGGGCGGCACCGGGGTGTGCCTGCCGGCCTGA
Protein Properties
Protein Residues: 215
Protein Molecular Weight: 23.5 kDa
Protein Theoretical pI: 5
Hydropathicity (GRAVY score): -0.243
Charge at pH 7 (predicted): -5.17
Protein Sequence: 
>PA5018
MVLRSEILTKKSELPTPDQALPGRESAMPVPEAHFVNGRPLTAPFPAGLQQVLFGMGCFWGAERRLWQQPGVWVTAVGYAGGYTPNPTYDEVCSGLTGHSEVVLVVYNPQETSFEQLLKVFWEAHDPTQGMRQGGDIGTQYRSVIYTFDAAQKAAAMASRESFQAELAKAGYDRITTEIADVPPFYYAEAYHQQYLAKNPNGYCGLGGTGVCLPA
References
External Links:
Resource Link
Genome ID: PA5018
Entrez Gene ID: 881240
NCBI Protein ID: 15600211
General Reference: PaperBLAST - Find papers about PA5018 and its homologs