Identification
Name: Protein methyltransferase hemK
Synonyms:
  • M.EcoKHemKP
  • Protein-(glutamine-N(5)) MTase hemK
  • Protein-glutamine N-methyltransferase hemK
Gene Name: hemK
Enzyme Class:
Biological Properties
General Function: Translation, ribosomal structure and biogenesis
Specific Function: Methylates the translation termination release factor RF1/PrfA on 'Gln-235' and RF2/PrfB on 'Gln-252'
Cellular Location: Cytoplasmic
KEGG Pathways:
  • reductive acetyl coenzyme A pathway CODH-PWY
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Thumb
    a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] ← an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein] + H+
    ReactionCard
    Complex Reactions: Not Available
    Transports: Not Available
    Metabolites:
    PAMDB IDNameView
    PAMDB000205S-AdenosylhomocysteineMetaboCard
    PAMDB000289S-AdenosylmethionineMetaboCard
    GO Classification:
    Function
    binding
    catalytic activity
    methyltransferase activity
    nucleic acid binding
    protein methyltransferase activity
    transferase activity
    transferase activity, transferring one-carbon groups
    Process
    cellular metabolic process
    macromolecule metabolic process
    macromolecule modification
    metabolic process
    methylation
    one-carbon metabolic process
    post-translational protein modification
    protein amino acid alkylation
    protein amino acid methylation
    protein modification process
    Gene Properties
    Locus tag: PA4664
    Strand: -
    Entrez Gene ID: 881353
    Accession: NP_253353.1
    GI: 15599859
    Sequence start: 5231653
    Sequence End: 5232483
    Sequence Length: 830
    Gene Sequence:
    >PA4664
    ATGACCACTATCTGTACCCTTCTCAAGGATTCCCAACTGCCCGATTCGCCCAGCGCCCGGCTCGACACCGAGTTGCTGCTGGCGGCGGCGATGGGCAAGCCGCGCAGCTTCCTGCGTACCTGGCCGGAGCGCATCGTGCCGCGCGAGGCCAACGAGCGGTTCGACGACTGGATCGCCCGTCGGCGCAACGGCGAGCCGGTGGCCTACATACTTGGCCACCAGGGCTTCTGGAGCCTGGACCTGGAGGTCGCGCCACACACCCTGATCCCGCGCCCGGACACCGAACTGCTGGTGGAAACCGCGCTGGCGACCCTCGCGGCGGACACCGCTACCGTGCTCGACCTGGGCACCGGCACCGGCGCCATCGCCCTGGCCCTGGCCAGCGAACGGCCGCTGTGGACGGTGACTGCGGTGGACCGCGTGGAAGAGGCCGTGGCGTTGGCCGAGCGCAATCGCCAGCGGCTGCTCCTGGAGAACGTCGAGGTGCGCCGCAGCCACTGGTTCTCCGCTCTCGATGGCCGACGCTTCCGGATGATCGTCGGCAATCCGCCGTATATCCCTGCCAGCGATCCGCACCTGAGCGAGGGCGACGTGCGTTTCGAGCCGAAGAGCGCGCTGGTCGCGGGTAGCGATGGCCTCGACGATATCCGCCAGATCGTCGCCCAGGCGCCGCGGCATTTGCTGGACGAAGGCTGGCTGCTGCTCGAGCACGGCTATGATCAAGGGGCGGCGGTGCGCGAACTGCTCGGCGCCCGCGGCTTCGCCGGGGTACATACGTTGCGCGACCTCGGCGGCAACGAGCGGATCACACTCGGACAATGGGCATGCTGA
    Protein Properties
    Protein Residues: 276
    Protein Molecular Weight: 30.5 kDa
    Protein Theoretical pI: 5.21
    Hydropathicity (GRAVY score): -0.168
    Charge at pH 7 (predicted): -7.37
    Protein Sequence:
    >PA4664
    MTTICTLLKDSQLPDSPSARLDTELLLAAAMGKPRSFLRTWPERIVPREANERFDDWIARRRNGEPVAYILGHQGFWSLDLEVAPHTLIPRPDTELLVETALATLAADTATVLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLENVEVRRSHWFSALDGRRFRMIVGNPPYIPASDPHLSEGDVRFEPKSALVAGSDGLDDIRQIVAQAPRHLLDEGWLLLEHGYDQGAAVRELLGARGFAGVHTLRDLGGNERITLGQWAC
    References
    External Links:
    Resource Link
    Genome ID: PA4664
    Entrez Gene ID: 881353
    NCBI Protein ID: 15599859
    General Reference: PaperBLAST - Find papers about PA4664 and its homologs