Identification |
Name: |
Protein methyltransferase hemK |
Synonyms: |
- M.EcoKHemKP
- Protein-(glutamine-N(5)) MTase hemK
- Protein-glutamine N-methyltransferase hemK
|
Gene Name: |
hemK |
Enzyme Class: |
|
Biological Properties |
General Function: |
Translation, ribosomal structure and biogenesis |
Specific Function: |
Methylates the translation termination release factor RF1/PrfA on 'Gln-235' and RF2/PrfB on 'Gln-252' |
Cellular Location: |
Cytoplasmic |
KEGG Pathways: |
- reductive acetyl coenzyme A pathway CODH-PWY
|
KEGG Reactions: |
Not Available |
SMPDB Reactions: |
Not Available |
PseudoCyc/BioCyc Reactions: |
| a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] ← an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein] + H +ReactionCard |
|
Complex Reactions: |
Not Available |
Transports: |
Not Available |
Metabolites: |
PAMDB ID | Name | View |
---|
PAMDB000205 | S-Adenosylhomocysteine | MetaboCard | PAMDB000289 | S-Adenosylmethionine | MetaboCard |
|
GO Classification: |
Function |
---|
binding | catalytic activity | methyltransferase activity | nucleic acid binding | protein methyltransferase activity | transferase activity | transferase activity, transferring one-carbon groups | Process |
---|
cellular metabolic process | macromolecule metabolic process | macromolecule modification | metabolic process | methylation | one-carbon metabolic process | post-translational protein modification | protein amino acid alkylation | protein amino acid methylation | protein modification process |
|
Gene Properties |
Locus tag: |
PA4664 |
Strand: |
- |
Entrez Gene ID: |
881353 |
Accession: |
NP_253353.1 |
GI: |
15599859 |
Sequence start: |
5231653 |
Sequence End: |
5232483 |
Sequence Length: |
830 |
Gene Sequence: |
>PA4664
ATGACCACTATCTGTACCCTTCTCAAGGATTCCCAACTGCCCGATTCGCCCAGCGCCCGGCTCGACACCGAGTTGCTGCTGGCGGCGGCGATGGGCAAGCCGCGCAGCTTCCTGCGTACCTGGCCGGAGCGCATCGTGCCGCGCGAGGCCAACGAGCGGTTCGACGACTGGATCGCCCGTCGGCGCAACGGCGAGCCGGTGGCCTACATACTTGGCCACCAGGGCTTCTGGAGCCTGGACCTGGAGGTCGCGCCACACACCCTGATCCCGCGCCCGGACACCGAACTGCTGGTGGAAACCGCGCTGGCGACCCTCGCGGCGGACACCGCTACCGTGCTCGACCTGGGCACCGGCACCGGCGCCATCGCCCTGGCCCTGGCCAGCGAACGGCCGCTGTGGACGGTGACTGCGGTGGACCGCGTGGAAGAGGCCGTGGCGTTGGCCGAGCGCAATCGCCAGCGGCTGCTCCTGGAGAACGTCGAGGTGCGCCGCAGCCACTGGTTCTCCGCTCTCGATGGCCGACGCTTCCGGATGATCGTCGGCAATCCGCCGTATATCCCTGCCAGCGATCCGCACCTGAGCGAGGGCGACGTGCGTTTCGAGCCGAAGAGCGCGCTGGTCGCGGGTAGCGATGGCCTCGACGATATCCGCCAGATCGTCGCCCAGGCGCCGCGGCATTTGCTGGACGAAGGCTGGCTGCTGCTCGAGCACGGCTATGATCAAGGGGCGGCGGTGCGCGAACTGCTCGGCGCCCGCGGCTTCGCCGGGGTACATACGTTGCGCGACCTCGGCGGCAACGAGCGGATCACACTCGGACAATGGGCATGCTGA |
Protein Properties |
Protein Residues: |
276 |
Protein Molecular Weight: |
30.5 kDa |
Protein Theoretical pI: |
5.21 |
Hydropathicity (GRAVY score): |
-0.168 |
Charge at pH 7 (predicted): |
-7.37 |
Protein Sequence: |
>PA4664
MTTICTLLKDSQLPDSPSARLDTELLLAAAMGKPRSFLRTWPERIVPREANERFDDWIARRRNGEPVAYILGHQGFWSLDLEVAPHTLIPRPDTELLVETALATLAADTATVLDLGTGTGAIALALASERPLWTVTAVDRVEEAVALAERNRQRLLLENVEVRRSHWFSALDGRRFRMIVGNPPYIPASDPHLSEGDVRFEPKSALVAGSDGLDDIRQIVAQAPRHLLDEGWLLLEHGYDQGAAVRELLGARGFAGVHTLRDLGGNERITLGQWAC |
References |
External Links: |
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General Reference: |
PaperBLAST - Find papers about PA4664 and its homologs
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