Glutamate 5-kinase (PA4565)

Identification
Name: Glutamate 5-kinase
Synonyms:
  • Gamma-glutamyl kinase
  • GK
Gene Name: proB
Enzyme Class:
Biological Properties
General Function: Involved in cellular amino acid biosynthetic process
Specific Function: Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+L-Glutamyl 5-phosphate+Thumb
Adenosine triphosphate + L-Glutamate ↔ ADP + L-Glutamyl 5-phosphate + L-Glutamic acid 5-phosphate
ReactionCard
SMPDB Reactions:
L-Glutamic acid+Thumb+Thumb → Adenosine diphosphate+Thumb+Thumb
L-Glutamic acid + Adenosine triphosphate + L-Glutamate → Adenosine diphosphate + γ-L-glutamyl 5-phosphate + ADP
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
Adenosine triphosphate + L-Glutamate → ADP + L-Glutamic acid 5-phosphate
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Adenosine triphosphate + L-Glutamate → ADP + L-Glutamic acid 5-phosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000304L-Glutamic acid 5-phosphateMetaboCard
PAMDB006312γ-L-glutamyl 5-phosphateMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
binding
catalytic activity
glutamate 5-kinase activity
nucleic acid binding
phosphotransferase activity, carboxyl group as acceptor
RNA binding
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
cellular amino acid and derivative metabolic process
cellular amino acid biosynthetic process
cellular amino acid metabolic process
cellular metabolic process
glutamine family amino acid metabolic process
metabolic process
proline biosynthetic process
proline metabolic process
Gene Properties
Locus tag: PA4565
Strand: -
Entrez Gene ID: 880909
Accession: NP_253255.1
GI: 15599761
Sequence start: 5113481
Sequence End: 5114599
Sequence Length: 1118
Gene Sequence: 
>PA4565
ATGCGGGACAAGGTGACTGGCGCGCGGCGCTGGGTGGTGAAGATCGGTAGCGCCCTGCTGACGGCCGATGGCCGTGGGCTGGATCGCAATGCCATGGCCGTTTGGGTCGAGCAGATGGTGGCGCTGCATTGCGCCGGCATCGAGCTGGTGCTGGTGTCGTCCGGCGCCGTCGCCGCCGGTATGAGCCGCCTGGGCTGGGTGTCCCGACCTAGCGCGATGCACGAACTCCAGGCCGCCGCCTCGGTGGGGCAAATGGGGTTGGTGCAGGCCTGGGAGTCCAGCTTCGCCCTGCATGGCCTGCAGACCGCCCAGGTGTTGCTGACCCATGACGACCTCTCCGACCGCAAGCGCTACCTGAACGCCCGCAGCACCCTGCGGACCCTGGTCGAGCTGGGCGTGGTCCCGGTGATCAACGAGAACGACACGGTGGTCACCGACGAGATCCGCTTCGGCGACAACGACACCCTGGCGGCACTGGTGGCCAACCTGGTCGAGGCCGACCTGCTGGTGATCCTTACCGATCGCGACGGGATGTTCGACGCCGATCCGCGCAACAATCCCGATGCCCAACTGATCTACGAGGCGCGTGCCGATGATCCGCAGCTCGATGCGGTGGCCGGCGGCAGTGCCGGCGCCCTGGGGCGCGGCGGAATGCAGACCAAGCTGCGGGCGGCGCGCCTGGCGGCGCGTTCCGGCGGGCATACGGTGATCGTCGGCGGGCGTATCGAGCGTGTCCTCGACCGCCTGCGCGCCGGCGAACGCCTCGGCACCCTGTTGACCCCTGATCGCAGTCGCAAGGCGGCGCGCAAGCAATGGCTGGCCGGCCACTTGCAGATGCGCGGCACCCTGGTGCTGGACGATGGGGCGGTGAAGGCGGTGAGCCAGGATCACAAGAGCCTGTTGCCGGTTGGGGTCAAGGCGGTCCAGGGCAGCTTCCGTCGCGGCGAGATGGTGGTCTGTGTGGACCAGGGCGGGCGCGAAGTGGCACGCGGCCTGGTCAACTACAGTGCGCTGGAGGCGCAGAAGATCCTCGGTCAGCCGACGGATGCCATCGAGGCCTTGCTCGGCTACGTGGATGGGCCGGAGCTGGTGCATCGCGACAATTTGGTTCTGGTCTGA
Protein Properties
Protein Residues: 372
Protein Molecular Weight: 39.8 kDa
Protein Theoretical pI: 7.28
Hydropathicity (GRAVY score): -0.015
Charge at pH 7 (predicted): 0.87
Protein Sequence: 
>PA4565
MRDKVTGARRWVVKIGSALLTADGRGLDRNAMAVWVEQMVALHCAGIELVLVSSGAVAAGMSRLGWVSRPSAMHELQAAASVGQMGLVQAWESSFALHGLQTAQVLLTHDDLSDRKRYLNARSTLRTLVELGVVPVINENDTVVTDEIRFGDNDTLAALVANLVEADLLVILTDRDGMFDADPRNNPDAQLIYEARADDPQLDAVAGGSAGALGRGGMQTKLRAARLAARSGGHTVIVGGRIERVLDRLRAGERLGTLLTPDRSRKAARKQWLAGHLQMRGTLVLDDGAVKAVSQDHKSLLPVGVKAVQGSFRRGEMVVCVDQGGREVARGLVNYSALEAQKILGQPTDAIEALLGYVDGPELVHRDNLVLV
References
External Links:
Resource Link
Genome ID: PA4565
Entrez Gene ID: 880909
NCBI Protein ID: 15599761
General Reference: PaperBLAST - Find papers about PA4565 and its homologs