Identification
Name: dihydroaeruginoic acid synthetase
Synonyms: Not Available
Gene Name: pchE
Enzyme Class: Not Available
Biological Properties
General Function: transport, pyochelin biosynthetic process, metabolic process
Specific Function: catalytic activity
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions: Not Available
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb
L-cysteine + ATP → cysteine-adenylate + diphosphate
ReactionCard
Thumb
a [PchE NRPS protein]-L-cysteine-S-salycilate → a PchE NRPS protein loaded with hydroxyphenyl-thiazoline + H2O + H+
ReactionCard
Thumb
cysteine-adenylate + a PchE non-ribosomal peptide synthase protein → a [PchE NRPS protein]-L-cysteine + AMP
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites: Not Available
GO Classification:
Function
catalytic activity
Process
transport
pyochelin biosynthetic process
metabolic process
Gene Properties
Locus tag: PA4226
Strand: -
Entrez Gene ID: 880048
Accession: NP_252916.1
GI: 15599422
Sequence start: 4736795
Sequence End: 4741111
Sequence Length: 4316
Gene Sequence:
>PA4226
ATGGATCTGCCCCCCGATTCCCGTACCGCCCTGCGCGACTGGCTGACCGAGCAGCTCGCCGACCTGCTCGGCGAACCGCTTGCTGACGTGCGCGCCCTGGCGGACGACGACGACCTGCTGGGCTGCGGCCTCGACTCGATCCGCCTGATGTACCTGCAGGAACGCCTGCGCGCGCGTGGCTCGACGCTGGACTTCGCCCAGTTGGCGCAGCGCCCCTGCCTGGGGGCCTGGCTCGACCTGCTGGCCTGCGCGGACCGGCTGTCCGCCCCGGCAACGGTCGCGCTGCCGACGGCGCAGGATCGCGATCAGCCGTTCGAGCTGTCTTCCGTGCAGCAGGCCTACTGGCTGGGACGTGGCGCCGGCGAGGTGCTGGGCAACGTCAGCTGCCATGCCTTTCTGGAATTCCGCACGCGGGATGTCGACCCGCAGCGCCTGGCCGCGGCGGCGGAGTGCGTGCGTCAACGCCACCCGATGTTGCGGGCGCGCTTCCTCGACGGTCGCCAGCAGATCCTTCCGACGCCGCCGCTGTCCTGCTTCGACCTGCAGGACTGGCGCACCTTACAGGTGGACGAGGCCGAGCGCGACTGGCAGGCGCTGCGCGACTGGCGCGCCCATGAATGCCTGGCGGTGGAGCGCGGCCAGGTGTTCCTGCTCGGGCTGGTGCGCATGCCGGGCGGCGAGGATCGCCTCTGGCTGAGTCTCGACCTGCTTGCCGCCGATGTCGAAAGCCTGCGCCTGCTGCTGGCCGAACTGGGCGTTGCCTACCTGGCGCCGGAGCGCCTGGCGGAGCCGCCGGCGCTGCATTTCGCCGACTACCTGGCGCACCGTGCGGCGCAACGCGCCGAGGCCGCGGCGCGGGCCCGCGACTACTGGCTGGAACGCCTGCCGCGCTTGCCGGACGCGCCGGCCCTGCCGTTGGCCTGCGCGCCGGAAAGCATCCGCCAGCCGCGCACCCGGCGCCTGGCATTCCAGCTTTCCGCCGGCGAGAGCCGGCGCCTGGAGCGTCTTGCCGCGCAGCATGGCGTGACCTTGTCCAGCGTGTTCGGCTGCGCCTTCGCGCTGGTCCTGGCGCGCTGGAGCGAAAGCGCGGAATTTCTCCTCAACGTGCCGTTGTTCGATCGGCATGCCGACGACCCGCGTATCGGCGAGGTGATCGCCGACTTCACCACCCTGTTGCTGCTGGAGTGCCGGATGCAGGCCGGGGTGTCCTTCGCCGAGGCGGTGAAGAGCTTCCAGCGCAACCTCCACGGAGCCATCGACCACGCCGCATTCCCCGCCCTGGAGGTGCTCCGCGAGGCGCGCCGGCAGGGCCAGCCACGCTCGGCGCCGGTGGTGTTCGCCAGCAACCTGGGCGAGGAGGGCTTCGTCCCGGCGGCCTTCCGCGACGCTTTCGGCGATCTCCACGACATGCTCTCGCAGACCCCGCAGGTCTGGCTCGACCACCAGCTCTACCGGGTGGGCGACGGTATCCTGCTGGCCTGGGATAGCGTCGTCGGCCTGTTCCCCGAAGGTCTGCCGGAAACCATGTTCGAAGCCTACGTGGGGCTGCTCCAGCGTCTCTGCGACAGCGCCTGGGGGCAGCCCGCCGATCTGCCGTTGCCCTGGGCGCAGCAGGCGCGCCGGGCCCTGCTCAACGGCCAGCCGGCATGCGCCACGGCGCGCACCCTGCATCGCGACTTCTTCCTTCGCGCCGCCGAGGCGCCGGATGCCGACGCGCTGCTCTATCGCGACCAACGTGTCACCCGCGGCGAACTGGCCGAGCGTGCGCTGCGCATCGCCGGCGGCCTGCGCGAAGCCGGGGTGCGCCCTGGCGACGCGGTCGAGGTCAGCCTGCCGCGCGGACCGCAGCAGGTCGCGGCGGTATTCGGCGTGCTCGCCGCAGGCGCCTGCTACGTGCCGCTGGACATCGACCAGCCGCCCGCACGGCGGCGCCTGATCGAAGAGGCCGCCGGGGTATGCCTGGCGATCACCGAGGAGGACGATCCGCAGGCCTTGCCGCCGCGCCTGGATGTCCAGCGCCTGCTGCGCGGCCCGGCGCTGGCCGCCCCCGTGCCGCTGGCGCCGCAGGCGAGTGCCTATGTGATCTACACCTCGGGCTCCACCGGGGTGCCCAAGGGCGTCGAGGTCAGCCACGCGGCGGCGATCAATACCATCGACGCGCTGCTCGACCTGCTGCGGGTGAACGCATCGGATCGCTTGCTGGCGGTCTCCGCGCTGGACTTCGATCTGTCGGTCTTCGACCTGTTCGGCGGCCTCGGCGCCGGTGCCAGCCTGGTCCTGCCGGCCCAGGAACAGGCGCGCGATGCCGCTGCCTGGGCGGAGGCTATCCAGCGGCATGCGGTGAGCCTGTGGAACTCGGCGCCGGCCTTGCTGGAGATGGCCCTCAGCCTGCCGGCGAGCCAGGCCGACTATCGCAGTCTGCGGGCGGTGCTGCTGTCCGGCGACTGGGTGGCCCTGGACCTGCCCGGCCGCCTGCGCCCACGTTGTGCCGAAGGCTGCCGCCTGCATGTGCTGGGTGGCGCTACCGAAGCGGGCATCTGGTCGAACCTGCAGAGCGTCGATACGGTGCCGCCGCACTGGCGTTCGATTCCCTACGGCCGGCCATTGCCGGGACAGGCCTACCGGGTGGTCGACACCCACGGGCGCGACGTGCCGGACCTGGTGGTCGGCGAGCTGTGGATCGGCGGCGCCAGCCTGGCCCGCGGCTATCGCAACGATCCCGAACTCAGCGCCCGGCGTTTCGTCCACGATGCCCAGGGCCGCTGGTATCGCACCGGCGATCGCGGTCGCTACTGGGGCGACGGTACCCTGGAATTCCTCGGTCGGGTCGACCAGCAGGTGAAAGTGCGCGGCCAGCGCATCGAGTTGGGCGAGGTGGAGGCCGCGCTGTGCGCCCAGGCTGGCGTGGAGAGCGCCTGCGCGGCGGTGCTCGGCGGTGGCGTGGCGAGCCTCGGCGCGGTGCTGGTACCGCGCCTGGCGCCACGGGCCGAAGGCTCCATGGATCTACCGGCCGCACAGCCCTTCGCCGGCCTGGCAGAGGCCGAGGCGGTACTCACCCGGGAAATCCTCGGCGCGCTGCTGGAGGCGCCGCTGGAGCTAGACGACGGTTTGCGCCGGCGCTGGCTGGACTGGCTAGCGGACTCCGCCGCCAGCGCGCTGCCGTCGCTCGACGAGGCGTTGCGCCGGCTCGGCTGGCAGGCCGCGGGGCTGACCGCGATGGGCAACGCTCTGCGCGGCCTGCTCGCCGGCGAACAGGCGCCGGCCGCGCTGCTCCTCGATCCCTGGCTGGCGCCGCAGGCGGTGGCCGCGCGCCTGCCGGACGGCCGCGAGGCCCTGGCGCGCCTGCTCGAAGCGCTGCCGACGCCGGCTGCCGGCGAACGCCTGCGGGTGGCGGTGCTGGATACCCGCGCCGGGCTCTGGCTCGACCAGGGCATGGCCTCGCTGTTGCGCCCAGGGCTGGAACTGACCCTCTTCGAACGCAGCCGCGTCCTCCTCGACGCCGCCGCCACCCGCTTGCCGGAACGGATCGTGGTGCAGGCGCTGGACGACGGCCTGCTACCTGCCGAGCACCTCGGTCGCTACGACCGGGTGATCAGCTTCGCCGCGCTGCACGCCTACGAGGCCAGCCGCGAAGGCCTGGCGCTGGCGGCGGCGCTGCTGCGCCCGCAGGGCCGCCTGTTGCTGGTGGACCTGCTATGCGAGTCGCCACTGGCGCTGCTCGGTGCGGCCTTGCTCGACGACCGGCCGCTGCGCCTGGCGGAGCTGCCGAGCCTGTTGGCCGATCTCGCCGCTGCGGGACTGGCGCCGCGTTGCCTGTGGCGCAGCGAGCGGATCGCCCTGGTCGAGGCGCTGGCACCGGGACTCGGGCTCGACGCCGCCGCGCTCCAGGCCGGCCTGGAGCAACGCCTGCCCCAGGCGATGCGGCCCGAACGCCTGTGGTGCCTGCCAAGCCTGCCGTTGAACGGCAATGGCAAGGTCGATCGTCGCCGCCTGGCCGAGAGCATGACCCGCGCACTCGGCGAGTGTCGTCACGAGCCCTCGGCGGAGGAGCCGCTGGAAGCCCATGAGCAAGCGCTGGCCGAGTGCTGGGAAGCGGTTCTCAAACGCCCGGTGCGTCGTCGCGAGGCGAGCTTCTTCAGCCTCGGCGGCGACAGCCTGCTGGCGACCCGCCTGCTGGCCGGCATACGTGAGCGTTTCGGCGTACGCCTGGGCATGGCCGACTTCTATCGCCAGCCGACCCTGGCCGGTCTTGCCCGCCACTTGCAGGTGCAGACCGTCGAAATCGAGGAAACCCAACTGGAAGAGGGCGTGCTATGA
Protein Properties
Protein Residues: 1438
Protein Molecular Weight: 156.4 kDa
Protein Theoretical pI: 5.08
Hydropathicity (GRAVY score): -0.004
Charge at pH 7 (predicted): -32.03
Protein Sequence:
>PA4226
MDLPPDSRTALRDWLTEQLADLLGEPLADVRALADDDDLLGCGLDSIRLMYLQERLRARGSTLDFAQLAQRPCLGAWLDLLACADRLSAPATVALPTAQDRDQPFELSSVQQAYWLGRGAGEVLGNVSCHAFLEFRTRDVDPQRLAAAAECVRQRHPMLRARFLDGRQQILPTPPLSCFDLQDWRTLQVDEAERDWQALRDWRAHECLAVERGQVFLLGLVRMPGGEDRLWLSLDLLAADVESLRLLLAELGVAYLAPERLAEPPALHFADYLAHRAAQRAEAAARARDYWLERLPRLPDAPALPLACAPESIRQPRTRRLAFQLSAGESRRLERLAAQHGVTLSSVFGCAFALVLARWSESAEFLLNVPLFDRHADDPRIGEVIADFTTLLLLECRMQAGVSFAEAVKSFQRNLHGAIDHAAFPALEVLREARRQGQPRSAPVVFASNLGEEGFVPAAFRDAFGDLHDMLSQTPQVWLDHQLYRVGDGILLAWDSVVGLFPEGLPETMFEAYVGLLQRLCDSAWGQPADLPLPWAQQARRALLNGQPACATARTLHRDFFLRAAEAPDADALLYRDQRVTRGELAERALRIAGGLREAGVRPGDAVEVSLPRGPQQVAAVFGVLAAGACYVPLDIDQPPARRRLIEEAAGVCLAITEEDDPQALPPRLDVQRLLRGPALAAPVPLAPQASAYVIYTSGSTGVPKGVEVSHAAAINTIDALLDLLRVNASDRLLAVSALDFDLSVFDLFGGLGAGASLVLPAQEQARDAAAWAEAIQRHAVSLWNSAPALLEMALSLPASQADYRSLRAVLLSGDWVALDLPGRLRPRCAEGCRLHVLGGATEAGIWSNLQSVDTVPPHWRSIPYGRPLPGQAYRVVDTHGRDVPDLVVGELWIGGASLARGYRNDPELSARRFVHDAQGRWYRTGDRGRYWGDGTLEFLGRVDQQVKVRGQRIELGEVEAALCAQAGVESACAAVLGGGVASLGAVLVPRLAPRAEGSMDLPAAQPFAGLAEAEAVLTREILGALLEAPLELDDGLRRRWLDWLADSAASALPSLDEALRRLGWQAAGLTAMGNALRGLLAGEQAPAALLLDPWLAPQAVAARLPDGREALARLLEALPTPAAGERLRVAVLDTRAGLWLDQGMASLLRPGLELTLFERSRVLLDAAATRLPERIVVQALDDGLLPAEHLGRYDRVISFAALHAYEASREGLALAAALLRPQGRLLLVDLLCESPLALLGAALLDDRPLRLAELPSLLADLAAAGLAPRCLWRSERIALVEALAPGLGLDAAALQAGLEQRLPQAMRPERLWCLPSLPLNGNGKVDRRRLAESMTRALGECRHEPSAEEPLEAHEQALAECWEAVLKRPVRRREASFFSLGGDSLLATRLLAGIRERFGVRLGMADFYRQPTLAGLARHLQVQTVEIEETQLEEGVL
References
External Links:
Resource Link
Genome ID: PA4226
Entrez Gene ID: 880048
NCBI Protein ID: 15599422
General Reference: PaperBLAST - Find papers about PA4226 and its homologs