Identification
Name: 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase
Synonyms: hpaE
Gene Name: hpcC
Enzyme Class: Not Available
Biological Properties
General Function: carbon utilization, 4-hydroxyphenylacetate metabolic process, cellular catabolic process, metabolic process, oxidation-reduction process, 4-hydroxyphenylacetate catabolic process
Specific Function: oxidoreductase activity, 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions: Not Available
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb
2-hydroxy-5-carboxymethylmuconate semialdehyde + NAD+ + H2O → 5-carboxymethyl-2-hydroxymuconate + NADH + 2 H+
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites: Not Available
GO Classification:
Function
oxidoreductase activity
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Process
carbon utilization
4-hydroxyphenylacetate metabolic process
cellular catabolic process
metabolic process
oxidation-reduction process
4-hydroxyphenylacetate catabolic process
Gene Properties
Locus tag: PA4123
Strand: +
Entrez Gene ID: 880100
Accession: NP_252812.1
GI: 15599318
Sequence start: 4611013
Sequence End: 4612473
Sequence Length: 1460
Gene Sequence:
>PA4123
ATGATCAAACACTGGATCAATGGCCGCGAGGTCGAAAGCAAGGACGTCTTCGAGAACTACAACCCGGCCACCGGCGAGCTGATCGGCGAGGTCGCCAGCGGCGGCGCGGCGGAAATCGACGCGGCGGTGGCGGCGGCCCGGGAAGCCTTCCCGAAATGGGCCAATACCCCGGCCAAGGAGCGCGCGCGCCTGATGCGCCGGCTCGGCGAGCTGATCGACCGGAACGTGCCGCACCTGGCGGAACTTGAGACCCTCGACACCGGCCTGCCGATCCACCAGACGAAGAACGTGCTGATCCCGCGCGCCTCGCACAACTTCGAGTTCTTCGCCGAAGTCTGCACGCGGATGAACGGGCACAGCTATCCGGTCGACGACCAGATGCTCAACTACACCCTGTACCAGCCGGTAGGCGTCTGCGGCCTGGTCTCGCCGTGGAACGTACCGTTCATGACCGCCACCTGGAAGACCGCGCCGTGCCTGGCGCTGGGCAACACGGCGGTGCTGAAGATGTCCGAGCTGTCGCCGCTGACCGCCAACGAGCTGGGCCGCCTGGTGCACGAGGCGGGCATTCCGCCGGGGGTGTTCAACGTGGTCCAGGGCTACGGCGCCAGCGCCGGCGACGCGCTGGTTCGCCACCGCGACGTGCGCGCGGTGTCCTTCACCGGCGGCACCGCCACCGGGCGACGGATCATGGAGGCGGCCGGGATCAAGAAATACTCGATGGAACTGGGCGGCAAGTCGCCGGTGCTGGTCTTCGAAGACGCCGACCTCGAGCGGGCGCTGGACGCCGCTCTGTTCACCATCTTCTCGCTGAACGGCGAGCGCTGCACCGCCGGCAGTCGCATCTTCGTCCAGGAAAGCGTCTACCCGCAGTTCGTCGCCGAGTTCGCCGCGCGCGCCAGGCGCCTGATCGTCGGCGATCCGCAGGACCCGAAGACCCAGGTCGGCTCGATGATCACCCAGGCCCACTACGACAAGGTCACCGGCTACATCCGCATCGGCCTCGAGGAAGGCGCCACCCTGGTGGCCGGCGGCCTGGAGCGTCCGGCCGGCCTGCCGGCGCACCTGAGCAAGGGGCAGTTCATCCAGCCCACGGTGTTCGCCGACGTGGACAACCGCATGCGCATCGCCCAGGAGGAGATCTTCGGCCCGGTGGTCTGCCTGATCCCGTTCAAGGACGAAGCCGAGGCGCTGCGCCTGGCCAACGACGTGGAATACGGCCTGGCCTCCTACATCTGGACCCAGGACATCGGCAAGGCCCATCGCCTGGCACGCGGCATCGAGGCCGGGATGGTCTTCATCAACAGCCAGAACGTGCGCGACCTGCGCCAGCCGTTCGGCGGGGTGAAGGCCTCGGGCACCGGACGCGAAGGCGGGGAATACAGCTTCGAGGTATTCGCCGAGATCAAGAACGTGTGTATATCCATGGGCAGCCATCACATCCCCCGCTGGGGCGTGTAG
Protein Properties
Protein Residues: 486
Protein Molecular Weight: 53 kDa
Protein Theoretical pI: 6.38
Hydropathicity (GRAVY score): -0.098
Charge at pH 7 (predicted): -4.28
Protein Sequence:
>PA4123
MIKHWINGREVESKDVFENYNPATGELIGEVASGGAAEIDAAVAAAREAFPKWANTPAKERARLMRRLGELIDRNVPHLAELETLDTGLPIHQTKNVLIPRASHNFEFFAEVCTRMNGHSYPVDDQMLNYTLYQPVGVCGLVSPWNVPFMTATWKTAPCLALGNTAVLKMSELSPLTANELGRLVHEAGIPPGVFNVVQGYGASAGDALVRHRDVRAVSFTGGTATGRRIMEAAGIKKYSMELGGKSPVLVFEDADLERALDAALFTIFSLNGERCTAGSRIFVQESVYPQFVAEFAARARRLIVGDPQDPKTQVGSMITQAHYDKVTGYIRIGLEEGATLVAGGLERPAGLPAHLSKGQFIQPTVFADVDNRMRIAQEEIFGPVVCLIPFKDEAEALRLANDVEYGLASYIWTQDIGKAHRLARGIEAGMVFINSQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEIKNVCISMGSHHIPRWGV
References
External Links:
Resource Link
Genome ID: PA4123
Entrez Gene ID: 880100
NCBI Protein ID: 15599318
General Reference: PaperBLAST - Find papers about PA4123 and its homologs