Identification
Name: 4-hydroxyphenylacetate 3-monooxygenase large chain p-hydroxyphenylacetate 3-hydroxylase
Synonyms: Not Available
Gene Name: hpaA
Enzyme Class: Not Available
Biological Properties
General Function: carbon utilization, 4-hydroxyphenylacetate metabolic process, cellular catabolic process, metabolic process, oxidation-reduction process, phenylacetate catabolic process
Specific Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, flavin adenine dinucleotide binding, acyl-CoA dehydrogenase activity, oxidoreductase activity, acting on the CH-CH group of donors
Cellular Location: Cytoplasmic
KEGG Pathways:
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Thumb
    4-hydroxyphenylacetate + NADH + oxygen = 3,4-dihydroxyphenylacetate + NAD+ + H2O
    ReactionCard
    Complex Reactions: Not Available
    Transports: Not Available
    Metabolites: Not Available
    GO Classification:
    Function
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    flavin adenine dinucleotide binding
    acyl-CoA dehydrogenase activity
    oxidoreductase activity, acting on the CH-CH group of donors
    Process
    carbon utilization
    4-hydroxyphenylacetate metabolic process
    cellular catabolic process
    metabolic process
    oxidation-reduction process
    phenylacetate catabolic process
    Gene Properties
    Locus tag: PA4091
    Strand: +
    Entrez Gene ID: 878727
    Accession: NP_252780.1
    GI: 15599286
    Sequence start: 4573741
    Sequence End: 4575303
    Sequence Length: 1562
    Gene Sequence:
    >PA4091
    ATGAAACCCGAAGATTTCCGTGCCTCTGCCACCCGTCCGTTCACCGGCGAGGAGTACCTCGCCAGCCTGCGCGACGACCGTGAGATCTACATCTACGGCGACCGCGTCAAGGACGTCACCAGCCACCCCGCCTTCCGCAACGCGGCCGCCTCCATGGCCCGGCTCTACGACGCCCTGCACGATCCGCAGAGCAAGGAAAAGCTCTGCTGGGAGACCGATACCGGCAACGGCGGCTATACCCACAAGTTCTTCCGCTACGCGCGCAGCGCCGACGAACTGCGCCAGCAGCGCGACGCCATCGCCGAGTGGTCGCGGCTGACCTACGGCTGGATGGGCCGCACCCCGGACTACAAGGCCGCCTTCGGCAGCGCCCTCGGCGCCAACCCGGGCTTCTACGGGCGTTTCGAGGACAACGCGAAAACCTGGTACAAGCGCATCCAGGAAGCCTGCCTGTACCTCAACCATGCCATCGTCAACCCGCCGATCGACCGCGACAAGCCGGTGGACCAGGTCAAGGACGTGTTCATCTCGGTGGACGAGGAAGTCGACGGCGGCATCGTCGTCAGCGGCGCCAAGGTGGTCGCCACGAATTCCGCGCTGACCCACTACAACTTCGTCGGCCAGGGTTCGGCGCAACTGCTCGGCGACAACACCGACTTCGCCCTGATGTTCATCGCGCCGATGAACACCCCCGGCATGAAGCTGATCTGCCGCCCCTCCTACGAACTGGTGGCGGGTATCGCCGGATCGCCGTTCGACTACCCGCTGTCCAGCCGTTTCGACGAGAACGACGCGATCCTGGTGATGGACAAGGTGTTCATCCCCTGGGAGAACGTACTGATCTACCGCGACTTCGAGCGCTGCAAGCAGTGGTTCCCCCAGGGTGGCTTCGGCCGGCTGTTCCCGATGCAGGGCTGCACCCGCCTGGCGGTCAAGCTCGACTTCATCACCGGCGCCCTCTACAAGGCCCTGCAATGCACCGGCTCCCTGGAGTTCCGCGGCGTGCAGGCGCAGGTCGGCGAAGTGGTGGCCTGGCGCAACCTGTTCTGGTCGCTGACCGACGCCATGTACGGCAACGCCAGCGAATGGCACGGCGGCGCCTTCCTGCCCAGCGCCGAGGCCCTGCAGGCCTACCGCGTGCTGGCGCCGCAGGCCTACCCGGAGATCAAGAAGACCATCGAGCAGGTGGTCGCCAGCGGCCTGATCTACCTGCCCTCCGGCGTTCGCGACCTGCACAATCCGCAACTCGACAAGTATCTCTCCACCTATTGCCGCGGCTCCGGCGGCATGGGCCACCGGGAGCGGATCAAGATCCTCAAGCTGCTCTGGGACGCCATCGGCAGCGAGTTCGGCGGCCGCCACGAGCTGTACGAGATCAACTACGCCGGCAGCCAGGACGAGATCCGCATGCAGGCCCTGCGCCAGGCGATCGGCAGCGGGGCGATGAAGGGCATGCTCGGCATGGTCGAGCAGTGCATGGGCGACTACGACGAGAACGGCTGGACCGTGCCGCACCTGCACAACCCGGACGACATCAACGTGCTCGATCGCATCCGCCAATGA
    Protein Properties
    Protein Residues: 520
    Protein Molecular Weight: 58.5 kDa
    Protein Theoretical pI: 6
    Hydropathicity (GRAVY score): -0.338
    Charge at pH 7 (predicted): -6.58
    Protein Sequence:
    >PA4091
    MKPEDFRASATRPFTGEEYLASLRDDREIYIYGDRVKDVTSHPAFRNAAASMARLYDALHDPQSKEKLCWETDTGNGGYTHKFFRYARSADELRQQRDAIAEWSRLTYGWMGRTPDYKAAFGSALGANPGFYGRFEDNAKTWYKRIQEACLYLNHAIVNPPIDRDKPVDQVKDVFISVDEEVDGGIVVSGAKVVATNSALTHYNFVGQGSAQLLGDNTDFALMFIAPMNTPGMKLICRPSYELVAGIAGSPFDYPLSSRFDENDAILVMDKVFIPWENVLIYRDFERCKQWFPQGGFGRLFPMQGCTRLAVKLDFITGALYKALQCTGSLEFRGVQAQVGEVVAWRNLFWSLTDAMYGNASEWHGGAFLPSAEALQAYRVLAPQAYPEIKKTIEQVVASGLIYLPSGVRDLHNPQLDKYLSTYCRGSGGMGHRERIKILKLLWDAIGSEFGGRHELYEINYAGSQDEIRMQALRQAIGSGAMKGMLGMVEQCMGDYDENGWTVPHLHNPDDINVLDRIRQ
    References
    External Links:
    Resource Link
    Genome ID: PA4091
    Entrez Gene ID: 878727
    NCBI Protein ID: 15599286
    General Reference: PaperBLAST - Find papers about PA4091 and its homologs